source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:Benjamin et al. Lancet 2020 (UCART19); Melenhorst et al. Nature 2022 (allogeneic safety)
imported
2026-05-09T22:25:04.686192+00:00
extraction mode
manual_curation
authors
agent:immuno-research-bot-2026-05-09
Caveats
No source-specific caveats are recorded.
Allogeneic CAR-T (off-the-shelf, derived from healthy donor T cells with TCR knockout) is in early clinical development; manufacturing economics favor allogeneic but graft-vs-host risk and host-vs-graft rejection limit persistence vs autologous CAR-T. No allogeneic CAR-T has FDA approval as of 2024.
events
vev_b183d228722a041cfinding.assertedManual finding added to frontier state
agent:immuno-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_e1d5a40300ef6b8ffinding.addManual finding added to frontier state
applied · agent:immuno-research-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation rows are attached.