source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:Brown et al. Nat Rev Cancer 2019 (solid-tumor CAR-T review); Rafiq et al. Nat Rev Clin Oncol 2020
imported
2026-05-09T22:24:34.737501+00:00
extraction mode
manual_curation
authors
agent:immuno-research-bot-2026-05-09
Caveats
No source-specific caveats are recorded.
Solid-tumor CAR-T faces consistent failure modes: limited tumor-antigen specificity (most antigens are also expressed on normal tissue), antigen heterogeneity, immunosuppressive microenvironment, and physical exclusion from tumor parenchyma. No solid-tumor CAR-T has produced phase 3 success as of 2024 outside select sarcoma case series.
events
vev_c983fbc81789ad26finding.assertedManual finding added to frontier state
agent:immuno-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_24c56af7d9b2bdb2finding.addManual finding added to frontier state
applied · agent:immuno-research-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation rows are attached.