source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:Lee et al. Biol Blood Marrow Transplant 2019 (ASTCT consensus grading); Maude et al. NEJM 2014
imported
2026-05-09T22:24:35.873903+00:00
extraction mode
manual_curation
authors
agent:immuno-research-bot-2026-05-09
Caveats
No source-specific caveats are recorded.
observational · vf_cae37e53a0c04493
Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS) are the dominant CAR-T toxicities; tocilizumab (anti-IL-6R) and corticosteroids manage CRS without abrogating CAR-T efficacy in approved indications. Standardized grading (ASTCT 2019) enables comparison across trials.
events
vev_8ced22e61ed7c3f8finding.assertedManual finding added to frontier state
agent:immuno-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_8fb4b07ac76f7d2afinding.addManual finding added to frontier state
applied · agent:immuno-research-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation rows are attached.