source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:Munshi et al. NEJM 2021 (ide-cel KarMMa); Berdeja et al. Lancet 2021 (cilta-cel CARTITUDE-1)
imported
2026-05-09T22:24:03.962001+00:00
extraction mode
manual_curation
authors
agent:immuno-research-bot-2026-05-09
Caveats
No source-specific caveats are recorded.
BCMA-targeted CAR-T (idecabtagene vicleucel, ciltacabtagene autoleucel) produces deep responses in heavily pretreated multiple myeloma; the class has extended CAR-T indications beyond CD19 lymphoid malignancies and shown that target choice and CAR design can mitigate antigen-loss escape with co-stimulation engineering.
events
vev_dafd911390925f43finding.assertedManual finding added to frontier state
agent:immuno-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_839c6a895b4acc96finding.addManual finding added to frontier state
applied · agent:immuno-research-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation rows are attached.