source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:Kantoff et al. NEJM 2010 (sipuleucel-T); review: Saxena et al. Nat Rev Cancer 2021
imported
2026-05-09T22:24:37.030636+00:00
extraction mode
manual_curation
authors
agent:immuno-research-bot-2026-05-09
Caveats
No source-specific caveats are recorded.
Vaccine-based cancer immunotherapy has produced limited efficacy except in specific contexts (sipuleucel-T in prostate cancer, BCG in non-muscle-invasive bladder cancer); the class has been outperformed by checkpoint inhibitors and adoptive cell therapy in most indications. Personalized neoantigen vaccines combined with checkpoint inhibition are an emerging area.
events
vev_889cfd79a0dec18cfinding.assertedManual finding added to frontier state
agent:immuno-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_fc48d71a508f7474finding.addManual finding added to frontier state
applied · agent:immuno-research-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation rows are attached.