source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:Larkin et al. NEJM 2015 (CheckMate 067 melanoma); Reck et al. NEJM 2016 (KEYNOTE-024 NSCLC); review: Sharma et al. Cell 2017
imported
2026-05-09T22:24:00.620468+00:00
extraction mode
manual_curation
authors
agent:immuno-research-bot-2026-05-09
Caveats
No source-specific caveats are recorded.
Anti-PD-1/PD-L1 monotherapy produces durable responses in approximately 20 percent of unselected patients across solid tumors; response rate stratifies by tumor mutational burden, MSI status, and PD-L1 expression but biomarker prediction remains imperfect.
events
vev_24420d835bd628d8finding.assertedManual finding added to frontier state
agent:immuno-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_6b95f364e5995671finding.addManual finding added to frontier state
applied · agent:immuno-research-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation rows are attached.