Proposed change
reason
v0.344 solo-maintainer pediatric entity-resolution wave: exact public identifier match for unresolved entity; clears needs_review without changing the assertion.
frontiers / frontier
Reviewable change
back to reviewAtypical teratoid/rhabdoid tumor (ATRT) of the CNS has biallelic SMARCB1 (INI1) loss in nearly all cases; SMARCA4 loss is the alternative driver in rare cases. Survival has improved with intensive chemotherapy + radiation in older children but infant ATRT remains very poor prognosis.
This is a proposal, not yet accepted frontier state. It names what it would change and who proposed it. Only an accepted review event, signed under reviewer authority, writes it into the frontier. Until then it carries no authority over the record.
Proposed change
reason
v0.344 solo-maintainer pediatric entity-resolution wave: exact public identifier match for unresolved entity; clears needs_review without changing the assertion.
Provenance
proposed by
reviewer:solo-maintainer
actor type
human
created at
2026-05-20
target type
finding
Affected finding
inspect finding →Atypical teratoid/rhabdoid tumor (ATRT) of the CNS has biallelic SMARCB1 (INI1) loss in nearly all cases; SMARCA4 loss is the alternative driver in rare cases. Survival has improved with intensive chemotherapy + radiation in older children but infant ATRT remains very poor prognosis.
vf_2260dd622b7ce258The diff is computed against current frontier state, the same diff a reviewer reads before deciding.
The live diff is computed from a writable workspace. This frontier is read-only here, so the change is shown as recorded without a recomputed before / after.
Canopus treats material changes like reviewable requests: one bounded packet, check output, reviewer decision, and accepted frontier effect.
Pediatric high-grade glioma: distinct biology, distinct trials receives a reviewable source, finding, caveat, replication, evaluation, or proof-affecting edit.
The packet names affected record objects, evidence, rationale, reviewer-facing fields, and expected proof impact.
Schema, provenance, benchmark, contradiction, and proof checks decide whether the request is ready to read.
A steward accepts, rejects, caveats, revises, or retracts the request under an inspectable identity.
Only the accepted event mutates frontier state. Atlases, constellations, and search update from that record state.