Proposed change
reason
NLM MeSH descriptor D008527 is the exact canonical descriptor for medulloblastoma.
frontiers / frontier
Reviewable change
back to reviewHippocampal-avoidance whole-brain radiotherapy reduces cognitive late effects in pediatric medulloblastoma craniospinal protocols and is now incorporated in NRG/COG protocols where oncologically feasible; the technique balances oncologic coverage of leptomeningeal disease with hippocampal sparing.
This is a proposal, not yet accepted frontier state. It names what it would change and who proposed it. Only an accepted review event, signed under reviewer authority, writes it into the frontier. Until then it carries no authority over the record.
Proposed change
reason
NLM MeSH descriptor D008527 is the exact canonical descriptor for medulloblastoma.
Provenance
proposed by
reviewer:solo-maintainer
actor type
human
created at
2026-05-20
target type
finding
Affected finding
inspect finding →Hippocampal-avoidance whole-brain radiotherapy reduces cognitive late effects in pediatric medulloblastoma craniospinal protocols and is now incorporated in NRG/COG protocols where oncologically feasible; the technique balances oncologic coverage of leptomeningeal disease with hippocampal sparing.
vf_58f662c710bb9661The diff is computed against current frontier state, the same diff a reviewer reads before deciding.
The live diff is computed from a writable workspace. This frontier is read-only here, so the change is shown as recorded without a recomputed before / after.
Canopus treats material changes like reviewable requests: one bounded packet, check output, reviewer decision, and accepted frontier effect.
Pediatric high-grade glioma: distinct biology, distinct trials receives a reviewable source, finding, caveat, replication, evaluation, or proof-affecting edit.
The packet names affected record objects, evidence, rationale, reviewer-facing fields, and expected proof impact.
Schema, provenance, benchmark, contradiction, and proof checks decide whether the request is ready to read.
A steward accepts, rejects, caveats, revises, or retracts the request under an inspectable identity.
Only the accepted event mutates frontier state. Atlases, constellations, and search update from that record state.