record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to staterecord state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding typeNo entity list is declared.
evidence
source-boundtheoretical · manual state transition
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
theoretical
conditions
Provenance
source title
Persson et al. 2022 (Neuro-oncology); Khairkhah et al. 2026 (Neoplasia)
authors
reviewer:will-blair
Pediatric HGGs display 'cold' immune microenvironments with low PD-1/PD-L1/CTLA-4 expression and low tumor mutational burden, explaining checkpoint inhibitor failures.
vs_061cddf1be44de97 · manual_curation
outgoing
vf_01f22a209c3a7756Cold immune TME with low checkpoint expression makes oncolytic virotherapy rationale (lower baseline immunosuppression) a more plausible escape route than ICIs
vf_d7f237c484db3663Cold immune microenvironment + low neoantigen load in pediatric HGG may render P-eIF2α modulation effective by inducing ER stress-mediated tumor apoptosis independent of immune targeting
incoming
supports · vf_945677df9a84a8b7
supports · vf_6d815c2d1decc76d
events
vev_70c7fb6776ee20b5finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_97732a4456fabe9cfinding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation record targets this finding id.