record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to stateno incoming links yet
record state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding typeNo entity list is declared.
evidence
source-boundtheoretical · manual state transition
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
theoretical
conditions
Provenance
source title
MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant DMG (Frontiers Oncology)
authors
reviewer:will-blair
MGMT promoter unmethylation and elevated MGMT expression confer resistance to temozolomide in H3K27M gliomas; three of four patient-derived DMG cell lines showed MGMT-driven TMZ resistance independent of MGMT methylation status
vs_d888fbb717a320da · manual_curation
outgoing
vf_f6fd98935260314bWhile TMZ resistance is well-documented via MGMT, ONC201 mechanisms bypass conventional alkylating-agent pathways, offering non-overlapping efficacy
incoming
No incoming links.
events
vev_8566a157106143a4finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_151c9a5039099b76finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation record targets this finding id.