record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to staterecord state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding typeNo entity list is declared.
evidence
source-boundtheoretical · manual state transition
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
theoretical
conditions
Provenance
source title
Exploring the tumor microenvironment in DIPG (PMC12164617)
authors
reviewer:will-blair
H3K27M-mutant gliomas exhibit minimal T-cell and NK-cell infiltration with predominantly M2-polarized macrophage accumulation, creating an immunologically 'cold' microenvironment with low PDL-1 expression and absent cytokine signaling
vs_6b661a0c55bf0f4a · manual_curation
outgoing
vf_2f0c819aebfe3b01The immunologically 'cold' TME suggests CAR-T efficacy may depend on engineered T-cell delivery rather than endogenous immune activation
incoming
events
vev_0d523a47bf3a06affinding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_339527fe876d53cafinding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation record targets this finding id.