record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to staterecord state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding typeNo entity list is declared.
evidence
source-boundtheoretical · manual state transition
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
theoretical
conditions
Provenance
source title
Buczkowicz et al. 2014 Nature Genetics; Mackay et al. 2016 Nature Communications
authors
reviewer:will-blair
TP53 mutations (~60%) and PPM1D truncating mutations (~30% of TP53 wild-type cases) are obligate partners of H3K27M in DIPG, arising clonally with H3K27M and maintained throughout tumor evolution.
vs_2d9590fda9f06305 · manual_curation
outgoing
vf_fb5016c2f917c1b4TP53/PPM1D co-mutation obligate with H3K27M; opportunity for p53 pathway targeting in TP53 wt cases
incoming
supports · vf_de03332c66323b46
depends · vf_5b9bf50c5abfd979
events
vev_fbd4fd45d7c4aee3finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_f8e76b9c356406acfinding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation record targets this finding id.