source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:BIOMEDE phase 2 international trial, Nature Medicine
imported
2026-05-29T02:50:59.251782+00:00
extraction mode
manual_curation
authors
reviewer:will-blair
Caveats
No source-specific caveats are recorded.
observational · vf_26edfbefc6b5cbb8
BIOMEDE trial (N=233, diffuse intrinsic pontine glioma): None of three targeted-therapy arms (erlotinib, dasatinib, everolimus) + radiation exceeded radiotherapy alone on primary OS endpoint, revealing fundamental inadequacy of single-pathway inhibition in pediatric HGG.
events
vev_ab360e1c6d555c30finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_0dac2db5f8628508finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.