source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
external sourcelocator
title:JCO integrated efficacy analysis; FDA accelerated approval dossier, 2025
imported
2026-05-29T02:50:57.593389+00:00
extraction mode
manual_curation
authors
reviewer:will-blair
Caveats
No source-specific caveats are recorded.
ONC201 (dordaviprone) demonstrates a 20% objective response rate and 40% disease control rate in pooled analyses of recurrent H3K27M-mutant diffuse midline glioma across five clinical trials (n=50), with median response duration of 11.2 months.
events
vev_f2d98404998f3d20finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_57675c02e6b3b86bfinding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.