source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:Characteristics of diffuse hemispheric gliomas, H3 G34-mutant in adults 2021 (10.1093/noajnl/vdab061); P16 immunohistochemistry is a sensitive and specific surrogate marker for CDKN2A homozygous deletion 2023 (10.1186/s40478-023-01573-2)
imported
2026-05-29T02:50:58.081892+00:00
extraction mode
manual_curation
authors
reviewer:will-blair
Caveats
No source-specific caveats are recorded.
observational · vf_467bafabec51e43b
H3G34-mutant hemispheric gliomas frequently acquire TP53 wildtype status and CDKN2A homozygous deletion but show lower incidence of MGMT methylation compared to adult IDH-wildtype glioblastomas, creating a distinct molecular signature with specific CDK4/6 inhibitor vulnerabilities.
events
vev_f076bd85ab87e06ffinding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_8f373d5b2f5a1453finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.