source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:Metabolic dependencies and neural progenitor dysregulation: driving forces in paediatric high-grade glioma development 2026 (10.1007/s10555-026-10325-2)
imported
2026-05-29T02:50:58.114130+00:00
extraction mode
manual_curation
authors
reviewer:will-blair
Caveats
No source-specific caveats are recorded.
H3G34-mutant hemispheric gliomas show altered metabolic dependencies including enhanced lipid metabolism and glucose utilization compared to K27M tumors; metabolic flexibility of glioma stem cells and cross-talk between metabolism and epigenetic regulation (α-ketoglutarate as H3K36me3 cofactor) creates distinct metabolic vulnerabilities.
events
vev_8f3b1728f5bce58ffinding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_1fe8d4a47b658777finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.