source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
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frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
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evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
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Locator and citation
locator
title:BIOMEDE trial exome sequencing and molecular architecture
imported
2026-05-29T02:50:59.325962+00:00
extraction mode
manual_curation
authors
reviewer:will-blair
Caveats
No source-specific caveats are recorded.
observational · vf_4171b4670921b306
Mandatory molecular profiling in BIOMEDE (exome sequencing, copy-number alterations) identified co-occurring pathway alterations and validated stratification—absence of biomarker-driven enrollment in prior adult-derived pediatric trials contributed to negative outcomes.
events
vev_e436e866bf38702ffinding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_e17e113ad0e3ce3dfinding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.