source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:Alternative lengthening of telomere-based immortalization renders H3G34R-mutant diffuse hemispheric glioma hypersensitive to PARP inhibitor combination regimens 2024 (10.1093/neuonc/noae228)
imported
2026-05-29T02:50:58.035747+00:00
extraction mode
manual_curation
authors
reviewer:will-blair
Caveats
No source-specific caveats are recorded.
H3G34R-mutant diffuse hemispheric gliomas are hypersensitive to PARP inhibitor combination regimens (palbociclib + olaparib or niraparib) due to alternative lengthening of telomeres (ALT)-driven ATRX-loss-associated DNA repair vulnerability; this is a distinct mechanistic vulnerability absent in K27M gliomas.
events
vev_7bac1ff0eb30bb9ffinding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_2024ccce0bc25611finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.