source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
external sourcelocator
title:Neuro-oncology mechanism review; pre-clinical in vitro assays
imported
2026-05-29T02:50:57.623843+00:00
extraction mode
manual_curation
authors
reviewer:will-blair
Caveats
No source-specific caveats are recorded.
H3K27M-mutant tumors show 2.5-fold greater sensitivity to ONC201 cytotoxicity (median IC50 ~0.6 µM) compared to wildtype H3 glioma cultures (median IC50 ~1.5 µM), indicating mutation-selective drug activity.
events
vev_2420e3fddae6745afinding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_39dd994eefd57485finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.