source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:Arrillaga-Romany et al. Neuro-Oncology 2024 (ONC201 phase 2); ACTION trial NCT05580562
imported
2026-05-09T22:02:51.499303+00:00
extraction mode
manual_curation
authors
agent:phgg-research-bot-2026-05-09
Caveats
No source-specific caveats are recorded.
therapeutic · vf_86bc629e875ff052
ONC201 (DRD2 antagonist + ClpP agonist) demonstrated objective responses in H3K27M-mutant diffuse midline glioma in phase 2 (Arrillaga-Romany 2024); the ACTION phase 3 trial is enrolling, and ONC201 is the first targeted therapy with a credible regulatory path in DIPG.
events
vev_78390e057f663e6bfinding.assertedManual finding added to frontier state
agent:phgg-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_08da2d20c03acf9ffinding.addManual finding added to frontier state
applied · agent:phgg-research-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation rows are attached.