frontiers / frontier
Reviewable change
back to reviewDonanemab (anti-pyroglutamate-Aβ MAb) shows positive primary endpoint in early symptomatic AD with low/medium tau PET burden. Tau PET stratification meaningfully modifies treatment effect — high-tau subgroup shows attenuated benefit. ARIA-E rate ~24%; APOE4-dose-dependent.
This is a proposal, not yet accepted frontier state. It names what it would change and who proposed it. Only an accepted review event, signed under reviewer authority, writes it into the frontier. Until then it carries no authority over the record.
Proposed change
reason
Donanemab TRAILBLAZER-ALZ 2 (Sims et al., JAMA 2023) demonstrated 35% slowing on iADRS in low/medium tau cohort and 22% in combined cohort over 18 months. Primary endpoint positive. Agent-drafted accept; eligible for human re-review.
Provenance
proposed by
agent:vela-curation-bot-2026-05-09
actor type
human
created at
2026-05-09
target type
finding
Affected finding
inspect finding →Donanemab (anti-pyroglutamate-Aβ MAb) shows positive primary endpoint in early symptomatic AD with low/medium tau PET burden. Tau PET stratification meaningfully modifies treatment effect — high-tau subgroup shows attenuated benefit. ARIA-E rate ~24%; APOE4-dose-dependent.
vf_e2554d6d7ec32686The diff is computed against current frontier state, the same diff a reviewer reads before deciding.
The live diff is computed from a writable workspace. This frontier is read-only here, so the change is shown as recorded without a recomputed before / after.
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Anti-amyloid translation in Alzheimer's disease receives a reviewable source, finding, caveat, replication, evaluation, or proof-affecting edit.
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