Anti-amyloid translation in Alzheimer's disease

CC-BY-4.0vfr_5076e7b3ff8e6b0f

id: vfr_5076e7b3ff8e6b0f
license: CC-BY-4.0
findings: 144
accepted core: 44
contested: 9

144

findings

links

125

sources

147

evidence

contested

0.63

avg conf

Anti-amyloid translation in Alzheimer's disease · Canopus

Review

Reviewable changes enter here with provenance and expected impact, are checked, and are accepted under human or verified-agent authority before they are written to accepted frontier state.

248

reviewable changes

244

open

resolved

accept events

Contribution lifecycle

The review queue is only one stage. A reviewable change becomes frontier state only after checks and reviewer authority write an accepted event.

01source / target
A source or target enters
A paper, dataset, protocol, result, note, gap, or benchmark target enters the engine as material for review.
inspect
02attempt
An attempt packet is produced
A human or agent run records input material, declared output material, environment, disclosures, logs, cost, and declared target.
inspect
03reviewable change
A record change is drafted
The attempt can produce a reviewable frontier change with affected findings, evidence, rationale, and proof impact.
inspect
04check
Checks inspect the change
Schema, evidence, contradiction, benchmark, and proof checks decide whether the edit is ready.
inspect
05review
A review event decides
A human or authorized reviewer accepts, rejects, caveats, or revises the reviewable change under authority.
inspect
06proof
Proof and maps update
The accepted event can now update proof freshness, citations, atlases, and constellations.
inspect

Review chain

Canopus treats material changes like reviewable requests: one bounded packet, check output, reviewer decision, and accepted frontier effect.

01request
Change request
Anti-amyloid translation in Alzheimer's disease receives a reviewable source, finding, caveat, replication, evaluation, or proof-affecting edit.
open review →
02packet
Diff packet
The packet names affected record objects, evidence, rationale, reviewer-facing fields, and expected proof impact.
open workbench →
03checks
Check output
Schema, provenance, benchmark, contradiction, and proof checks decide whether the request is ready to read.
inspect checks →
04review
Reviewer decision
A steward accepts, rejects, caveats, revises, or retracts the request under an inspectable identity.
read queue →
05accepted
Accepted event
Only the accepted event mutates frontier state. Atlases, constellations, and search update from that record state.
inspect events →

proposedunder reviewacceptedcontestedunreviewedretracted

Open · 244

finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_0014e47ebf928b0a
→
vf_7b4bfdf919b22af5
Reviewed for decision-console use: bounded TRAILBLAZER-ALZ 2 benefit claim with trial population and biomarker-selection scope.
contribution class
review
applied
source and evidence
vf_7b4bfdf919b22af5
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_0014e47ebf928b0a
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewagent:vela-curation-bot-2026-05-092026-05-09
id
vpr_02cc6836a2d1d57f
→
vf_3d380bcccbe5850e
Verubecestat EPOCH (Egan et al., NEJM 2018) and APECS were halted for futility, establishing BACE1 inhibition as a failed translation arm. The failed-trial finding is well-supported. Agent-drafted accept; eligible for human re-review.
contribution class
review
applied
source and evidence
vf_3d380bcccbe5850e
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:vela-curation-bot-2026-05-09
reviewable change id vpr_02cc6836a2d1d57f
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_0333bc1f9cf1302d
→
vf_db2866d2108e395b
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_db2866d2108e395b
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_0333bc1f9cf1302d
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_0565cc781bdf7f69
→
vf_a88406847e7d5cd5
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_a88406847e7d5cd5
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_0565cc781bdf7f69
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:scienceclaw-demo2026-05-06
id
vpr_063ddcbfa5c6e5eb
→
va_e2baec9b96a06208
Import artifact scaa_artifact_001 from artifact packet cap_9633575b0bead5b7
contribution class
source artifact
applied
source and evidence
va_e2baec9b96a06208
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:scienceclaw-demo
reviewable change id vpr_063ddcbfa5c6e5eb
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_073fe27e3062e803
→
vf_806ac99cdbc7ad59
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_806ac99cdbc7ad59
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_073fe27e3062e803
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_091f37ad545a0d04
→
vf_e46485c320b6b4ff
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_e46485c320b6b4ff
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_091f37ad545a0d04
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_0996ef1dd134f055
→
vf_29671540d388fc5d
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_29671540d388fc5d
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_0996ef1dd134f055
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_0b31053ba6f0303d
→
vf_44f615c2e6b934e7
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_44f615c2e6b934e7
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_0b31053ba6f0303d
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_0c0f2d7e59449cda
→
vf_624f7ed44a262689
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_624f7ed44a262689
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_0c0f2d7e59449cda
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_0c933959d5dd71ab
→
vf_98bca71097f11704
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_98bca71097f11704
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_0c933959d5dd71ab
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_0fbbede3a7e0c8ef
→
vf_092bd1220b85fda6
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_092bd1220b85fda6
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_0fbbede3a7e0c8ef
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewagent:vela-curation-bot-2026-05-092026-05-09
id
vpr_1024419a835feaec
→
vf_e2554d6d7ec32686
Donanemab TRAILBLAZER-ALZ 2 (Sims et al., JAMA 2023) demonstrated 35% slowing on iADRS in low/medium tau cohort and 22% in combined cohort over 18 months. Primary endpoint positive. Agent-drafted accept; eligible for human re-review.
contribution class
review
applied
source and evidence
vf_e2554d6d7ec32686
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:vela-curation-bot-2026-05-09
reviewable change id vpr_1024419a835feaec
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_12931a6601a7c828
→
vf_b299e3ad7965e4d7
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_b299e3ad7965e4d7
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_12931a6601a7c828
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_136fd4346d61dc53
→
vf_3cae9b229e0412cf
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_3cae9b229e0412cf
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_136fd4346d61dc53
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.caveatcontestedreviewer:will-blair-bot2026-05-06
id
vpr_14efe481b72d9e44
→
vf_7b4bfdf919b22af5
Decision-console scope: this supports a bounded early symptomatic donanemab claim under amyloid/tau selection criteria; it does not remove the need to inspect ARIA risk, treatment discontinuation rules, and endpoint meaningfulness.
contribution class
frontier change
applied
source and evidence
vf_7b4bfdf919b22af5
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_14efe481b72d9e44
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_15312fab51cde813
→
vf_3d254efae19793ea
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_3d254efae19793ea
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_15312fab51cde813
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_16a864c07facc4b8
→
vf_c3d9e665f63f045e
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_c3d9e665f63f045e
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_16a864c07facc4b8
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_19efd08ab5224ffc
→
vf_10d9f97f1c08783f
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_10d9f97f1c08783f
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_19efd08ab5224ffc
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedagent:scienceclaw-shaped-demo2026-05-06
id
vpr_1a553b43b6cc1262
→
vf_8f771d0c7c3c3630
Candidate claim sc_claim_benefit_risk_bound imported from artifact packet cap_anti_amyloid_scienceclaw_demo
contribution class
extraction
applied
source and evidence
vf_8f771d0c7c3c3630
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:scienceclaw-shaped-demo
reviewable change id vpr_1a553b43b6cc1262
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_1baa2624cf41becc
→
vf_a0f9919e6d163b8d
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_a0f9919e6d163b8d
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_1baa2624cf41becc
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_1c7bf6ab5ab29cd3
→
vf_6aff53d375659bcf
Needs quantitative per-trial effect table before it should be treated as settled.
contribution class
review
applied
source and evidence
vf_6aff53d375659bcf
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_1c7bf6ab5ab29cd3
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_1cdb7be6b81b9c26
→
vf_3dcfa7fb41b3b39c
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_3dcfa7fb41b3b39c
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_1cdb7be6b81b9c26
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.noteunreviewedreviewer:will-blair-bot2026-05-06
id
vpr_1d0faeb172ca1b81
→
vf_4d8aa40cc734ab93
Review regulatory source record delta for reg-fda-aducanumab from run sir_4c5bbc2d54bb56be
contribution class
frontier change
applied
source and evidence
vf_4d8aa40cc734ab93
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_1d0faeb172ca1b81
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_213966f92cf8436f
→
vf_1b37c93a4f619a86
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_1b37c93a4f619a86
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_213966f92cf8436f
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_21bd44361e2c2994
→
vf_0f4099b0c5f58629
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_0f4099b0c5f58629
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_21bd44361e2c2994
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.entity_resolveunreviewedreviewer:will-blair2026-05-10
id
vpr_21d0c76335044d59
→
vf_155dd090fb7c6ff7
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
contribution class
frontier change
applied
source and evidence
vf_155dd090fb7c6ff7
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair
reviewable change id vpr_21d0c76335044d59
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedagent:scienceclaw-demo2026-05-06
id
vpr_22bf87f2e71cbb52
→
vf_ac19cd84e851d13d
Candidate claim claim_001 imported from artifact packet cap_9633575b0bead5b7
contribution class
extraction
applied
source and evidence
vf_ac19cd84e851d13d
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:scienceclaw-demo
reviewable change id vpr_22bf87f2e71cbb52
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_22c5a651dca0850f
→
vf_47cdd5e5bf246fe0
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_47cdd5e5bf246fe0
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_22c5a651dca0850f
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.caveatcontestedreviewer:will-blair-bot2026-05-06
id
vpr_23818765259c6029
→
vf_29671540d388fc5d
Decision-console scope: CDR-SB meaningfulness thresholds are a decision constraint, not a settled universal cutoff; different stakeholders may weight cognition, function, safety, and monitoring burden differently.
contribution class
frontier change
applied
source and evidence
vf_29671540d388fc5d
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_23818765259c6029
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_23f13402a312af3a
→
vf_c28c3900913c3a26
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_c28c3900913c3a26
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_23f13402a312af3a
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_243c0195a9f529ae
→
vf_3dcfa7fb41b3b39c
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_3dcfa7fb41b3b39c
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_243c0195a9f529ae
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_25b9922e459f7974
→
vf_b10935043fb06532
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_b10935043fb06532
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_25b9922e459f7974
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_26b5501c9e58397b
→
vf_56f893a9fe9651de
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_56f893a9fe9651de
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_26b5501c9e58397b
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_26dfdf946cb807a7
→
vf_59f9854299f25567
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_59f9854299f25567
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_26dfdf946cb807a7
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_27e923d783802de2
→
vf_1bed25f7fc003a7c
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_1bed25f7fc003a7c
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_27e923d783802de2
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_28b3f40cd1e93195
→
vf_4abaa170d4f846a4
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_4abaa170d4f846a4
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_28b3f40cd1e93195
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:reviewer:will-blair-bot2026-05-06
id
vpr_2913d6425eca05ee
→
va_c8941a3227e50131
Import artifact clinicaltrials_gov_v2_NCT01739348 from artifact packet cap_818a078e8b9d8ed6
contribution class
source artifact
applied
source and evidence
va_c8941a3227e50131
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:reviewer:will-blair-bot
reviewable change id vpr_2913d6425eca05ee
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewagent:vela-curation-bot-2026-05-092026-05-09
id
vpr_2cdb867070054ee0
→
vf_b5b25525daef5712
Solanezumab EXPEDITION (Doody et al., NEJM 2014) and EXPEDITION3 (Honig et al., NEJM 2018) negative on primary cognitive endpoints. The failure is itself well-established and important for the translation gap. Agent-drafted accept; eligible for human re-review.
contribution class
review
applied
source and evidence
vf_b5b25525daef5712
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:vela-curation-bot-2026-05-09
reviewable change id vpr_2cdb867070054ee0
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_2ce006ffa5c100e5
→
vf_7b4bfdf919b22af5
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_7b4bfdf919b22af5
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_2ce006ffa5c100e5
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:reviewer:will-blair-bot2026-05-06
id
vpr_2d255c5551c3efe1
→
va_593a134a827a47d1
Import artifact clinicaltrials_gov_v2_NCT04437511 from artifact packet cap_818a078e8b9d8ed6
contribution class
source artifact
applied
source and evidence
va_593a134a827a47d1
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:reviewer:will-blair-bot
reviewable change id vpr_2d255c5551c3efe1
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_2f6a605aba5c0a5e
→
vf_1a157cadb4059087
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_1a157cadb4059087
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_2f6a605aba5c0a5e
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.entity_resolveunreviewedreviewer:will-blair2026-05-10
id
vpr_2f7d6c9d2760d2ed
→
vf_5142fb9694998132
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
contribution class
frontier change
applied
source and evidence
vf_5142fb9694998132
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair
reviewable change id vpr_2f7d6c9d2760d2ed
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_304c4fa4eb4a44e0
→
vf_74496f743b81b0ee
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_74496f743b81b0ee
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_304c4fa4eb4a44e0
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_30abdd90b149d56f
→
vf_3e548b0a1c8ee3b2
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_3e548b0a1c8ee3b2
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_30abdd90b149d56f
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_31a2cebaa5d38622
→
vf_fffb0c87a18ef6e6
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_fffb0c87a18ef6e6
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_31a2cebaa5d38622
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_339ba6b774ad10b4
→
vf_a9203e156f10cb62
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_a9203e156f10cb62
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_339ba6b774ad10b4
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_33aefa0b61c292a0
→
vf_78e8d7300689c72f
Reviewed as a class-tension candidate against positive antibody programs.
contribution class
review
applied
source and evidence
vf_78e8d7300689c72f
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_33aefa0b61c292a0
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_3430bcdaf65c4f67
→
vf_3bbf2c4761c9867f
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_3bbf2c4761c9867f
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_3430bcdaf65c4f67
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.confidence_reviseunreviewedreviewer:will-blair-bot2026-05-06
id
vpr_3617fc251a9084fa
→
vf_6aff53d375659bcf
Cross-program pattern is strong, but quantitative synthesis remains incomplete.
contribution class
frontier change
applied
source and evidence
vf_6aff53d375659bcf
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_3617fc251a9084fa
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_36d51eb4dcbcbc0c
→
vf_a1145511f633c0df
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_a1145511f633c0df
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_36d51eb4dcbcbc0c
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_371b4e01866e4d94
→
vf_03875dbe6be66b00
Reviewed for decision-console use: failed BACE program claim is scoped to verubecestat EPOCH-style clinical failure, not all anti-amyloid mechanisms.
contribution class
review
applied
source and evidence
vf_03875dbe6be66b00
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_371b4e01866e4d94
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.caveatcontestedreviewer:will-blair-bot2026-05-06
id
vpr_37cfb989338834e7
→
vf_9ded3333a52f3e58
Clinical effect is modest and should be interpreted with ARIA risk, monitoring load, and eligibility constraints.
contribution class
frontier change
applied
source and evidence
vf_9ded3333a52f3e58
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_37cfb989338834e7
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_38e6bdfb3c6b32ab
→
vf_ee9deb4e3c016569
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_ee9deb4e3c016569
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_38e6bdfb3c6b32ab
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_3915a57b568c833b
→
vf_e0683bf56937bdc3
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_e0683bf56937bdc3
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_3915a57b568c833b
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_393c299e51a05923
→
vf_821c331e449f53b8
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_821c331e449f53b8
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_393c299e51a05923
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_3969c44c787e15e6
→
vf_c7f8be49ea6547d8
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_c7f8be49ea6547d8
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_3969c44c787e15e6
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_396b5b07382da500
→
vf_9a4c5010e77212f3
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_9a4c5010e77212f3
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_396b5b07382da500
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_3ac95fdf616023a7
→
vf_4d8aa40cc734ab93
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_4d8aa40cc734ab93
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_3ac95fdf616023a7
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedagent:bbb-curation-bot-2026-05-092026-05-09
id
vpr_3cd1d4f810329662
→
vf_5142fb9694998132
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_5142fb9694998132
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:bbb-curation-bot-2026-05-09
reviewable change id vpr_3cd1d4f810329662
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_3ee126bc14fcdbdd
→
vf_4604d8f3b8f92a86
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_4604d8f3b8f92a86
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_3ee126bc14fcdbdd
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_3fcd40e83d26271c
→
vf_44f615c2e6b934e7
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_44f615c2e6b934e7
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_3fcd40e83d26271c
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_407ab1b16611f4d6
→
vf_efad6b4cb4927b3a
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_efad6b4cb4927b3a
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_407ab1b16611f4d6
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:agent-discourse-demo2026-05-06
id
vpr_40edb55b5ca713e8
→
va_7c5a5b6aeb69a0ad
Import artifact disc_review_001 from artifact packet cap_c8affa0f8ff7273f
contribution class
source artifact
applied
source and evidence
va_7c5a5b6aeb69a0ad
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:agent-discourse-demo
reviewable change id vpr_40edb55b5ca713e8
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedagent:scienceclaw-demo2026-05-06
id
vpr_4246c4e7bd7bdefa
→
vf_f62560b9a73eae49
Open need need_001 imported from artifact packet cap_9633575b0bead5b7
contribution class
extraction
applied
source and evidence
vf_f62560b9a73eae49
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:scienceclaw-demo
reviewable change id vpr_4246c4e7bd7bdefa
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_462ac80699b1dc1e
→
vf_eab6319d42696ba9
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_eab6319d42696ba9
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_462ac80699b1dc1e
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:reviewer:will-blair-bot2026-05-06
id
vpr_477feb6c4f7dc7be
→
va_6041abc063b976e3
Import artifact sir_68a1577de35d0d91_manifest from artifact packet cap_818a078e8b9d8ed6
contribution class
source artifact
applied
source and evidence
va_6041abc063b976e3
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:reviewer:will-blair-bot
reviewable change id vpr_477feb6c4f7dc7be
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.caveatcontestedreviewer:will-blair-bot2026-05-06
id
vpr_47e89f04337c7786
→
vf_03875dbe6be66b00
Decision-console scope: verubecestat is used here as a failed BACE program exemplar; the correction path should not generalize this single result to every amyloid-lowering approach.
contribution class
frontier change
applied
source and evidence
vf_03875dbe6be66b00
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_47e89f04337c7786
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_47f4147afcd7c0ab
→
vf_247ab84f7a601b89
Reviewed as amyloid-pathway translation tension, not as a direct antibody contradiction.
contribution class
review
applied
source and evidence
vf_247ab84f7a601b89
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_47f4147afcd7c0ab
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_49e23f5a2b2007ad
→
vf_2e7192704f1767e4
Reviewed for decision-console use: ARIA/APOE4 risk claim is scoped to anti-amyloid antibody monitoring and stratification.
contribution class
review
applied
source and evidence
vf_2e7192704f1767e4
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_49e23f5a2b2007ad
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_4a8226dd86ebd82b
→
vf_d35b8235e5093334
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_d35b8235e5093334
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_4a8226dd86ebd82b
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_4ada0b1e7d5c5acd
→
vf_afddbeabc19efa09
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_afddbeabc19efa09
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_4ada0b1e7d5c5acd
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:reviewer:will-blair-bot2026-05-06
id
vpr_4ae869d8842a0433
→
va_81f307d50e0d0ba7
Import artifact clinicaltrials_gov_v2_NCT04468659 from artifact packet cap_818a078e8b9d8ed6
contribution class
source artifact
applied
source and evidence
va_81f307d50e0d0ba7
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:reviewer:will-blair-bot
reviewable change id vpr_4ae869d8842a0433
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_4c253b0b824aafb2
→
vf_56f893a9fe9651de
Very small human sample; delivery signal should not be generalized.
contribution class
review
applied
source and evidence
vf_56f893a9fe9651de
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_4c253b0b824aafb2
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:agent-discourse-demo2026-05-06
id
vpr_4c56c9555d3438de
→
va_d38112bf6bba0b2a
Import artifact disc_post_001 from artifact packet cap_c8affa0f8ff7273f
contribution class
source artifact
applied
source and evidence
va_d38112bf6bba0b2a
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:agent-discourse-demo
reviewable change id vpr_4c56c9555d3438de
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_4de62edfe4cabc47
→
vf_a9e6894fb47b3dff
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_a9e6894fb47b3dff
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_4de62edfe4cabc47
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_51af45c632c05070
→
vf_f738e7618b5339b8
Parallel phase 3 trials were discordant; preserve plural interpretation.
contribution class
review
applied
source and evidence
vf_f738e7618b5339b8
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_51af45c632c05070
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_52272470ae065dbd
→
vf_29671540d388fc5d
Threshold differs by disease stage and stakeholder; keep as review lead.
contribution class
review
applied
source and evidence
vf_29671540d388fc5d
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_52272470ae065dbd
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_52770b40692072c6
→
vf_cf2675d2e90a6d9f
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_cf2675d2e90a6d9f
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_52770b40692072c6
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.entity_resolveunreviewedreviewer:will-blair2026-05-10
id
vpr_53876d5d4438345c
→
vf_5142fb9694998132
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings. Amyloid-beta is the cleavage product of APP; the UniProt entry P05067 is the canonical anchor for the parent protein and the standard reference for amyloid-beta peptide research.
contribution class
frontier change
applied
source and evidence
vf_5142fb9694998132
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair
reviewable change id vpr_53876d5d4438345c
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_54d7d91711dee883
→
vf_db0700daf56cff9a
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_db0700daf56cff9a
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_54d7d91711dee883
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_5577cfa003365b87
→
vf_2ac35ecfb0c1503a
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_2ac35ecfb0c1503a
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_5577cfa003365b87
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_557b5bc4cde937ca
→
vf_812f09f1fd585c2d
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_812f09f1fd585c2d
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_557b5bc4cde937ca
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_55fc599c3cd36861
→
vf_0767356cc73a6387
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_0767356cc73a6387
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_55fc599c3cd36861
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_572854aaebd2536f
→
vf_10d9f97f1c08783f
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_10d9f97f1c08783f
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_572854aaebd2536f
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_5746e9e421a701c4
→
vf_eab6319d42696ba9
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_eab6319d42696ba9
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_5746e9e421a701c4
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_58d3076bd3291e84
→
vf_901cc5b7f2eaef25
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_901cc5b7f2eaef25
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_58d3076bd3291e84
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_597e1d5c0e8b9baf
→
vf_efc1efa13b82ec1b
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_efc1efa13b82ec1b
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_597e1d5c0e8b9baf
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_5a7ac40e644f2600
→
vf_5329fc49a509f89e
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_5329fc49a509f89e
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_5a7ac40e644f2600
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_5ba6564481b03de7
→
vf_723edf56419950be
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_723edf56419950be
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_5ba6564481b03de7
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_5c8667776a610821
→
vf_b56e4c6ab7f42e14
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_b56e4c6ab7f42e14
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_5c8667776a610821
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.entity_resolveunreviewedreviewer:will-blair2026-05-10
id
vpr_5d60f1d220d27332
→
vf_155dd090fb7c6ff7
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
contribution class
frontier change
applied
source and evidence
vf_155dd090fb7c6ff7
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair
reviewable change id vpr_5d60f1d220d27332
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_5e921e957ea492cb
→
vf_c8bc589dc291ef29
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_c8bc589dc291ef29
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_5e921e957ea492cb
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_5fb00cc0c77deb31
→
vf_03aac0ab77ae80e8
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_03aac0ab77ae80e8
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_5fb00cc0c77deb31
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:scienceclaw-demo2026-05-06
id
vpr_5fc6378988e7d7fa
→
va_b653e17f22c00c79
Import artifact scaa_artifact_003 from artifact packet cap_9633575b0bead5b7
contribution class
source artifact
applied
source and evidence
va_b653e17f22c00c79
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:scienceclaw-demo
reviewable change id vpr_5fc6378988e7d7fa
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_5fdd386b6da77f47
→
vf_c10aaeb89e6aa587
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_c10aaeb89e6aa587
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_5fdd386b6da77f47
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:reviewer:will-blair-bot2026-05-06
id
vpr_5feb471888a7db25
→
va_f15234e27be15331
Import artifact clinicaltrials_gov_v2_NCT03887455 from artifact packet cap_818a078e8b9d8ed6
contribution class
source artifact
applied
source and evidence
va_f15234e27be15331
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:reviewer:will-blair-bot
reviewable change id vpr_5feb471888a7db25
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_6038f75915228249
→
vf_f96196fcce0ed389
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_f96196fcce0ed389
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_6038f75915228249
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.entity_resolveunreviewedreviewer:will-blair2026-05-10
id
vpr_60e0f12e762d259c
→
vf_61249fb410ed2d52
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
contribution class
frontier change
applied
source and evidence
vf_61249fb410ed2d52
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair
reviewable change id vpr_60e0f12e762d259c
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:agent-discourse-demo2026-05-06
id
vpr_612009eefdc6402f
→
va_56840a4b7b09d891
Import artifact disc_comment_001 from artifact packet cap_c8affa0f8ff7273f
contribution class
source artifact
applied
source and evidence
va_56840a4b7b09d891
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:agent-discourse-demo
reviewable change id vpr_612009eefdc6402f
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedagent:bbb-curation-bot-2026-05-092026-05-09
id
vpr_647281164d2a42d4
→
vf_155dd090fb7c6ff7
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_155dd090fb7c6ff7
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:bbb-curation-bot-2026-05-09
reviewable change id vpr_647281164d2a42d4
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.entity_resolveunreviewedreviewer:will-blair2026-05-10
id
vpr_6643982ceecb840e
→
vf_61249fb410ed2d52
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
contribution class
frontier change
applied
source and evidence
vf_61249fb410ed2d52
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair
reviewable change id vpr_6643982ceecb840e
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_66897775e0b0b458
→
vf_f105dd8fd726a462
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_f105dd8fd726a462
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_66897775e0b0b458
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:reviewer:will-blair-bot2026-05-06
id
vpr_694eb9781b8b82ed
→
va_240bbf54bbc083ec
Import artifact clinicaltrials_gov_v2_NCT02477800 from artifact packet cap_818a078e8b9d8ed6
contribution class
source artifact
applied
source and evidence
va_240bbf54bbc083ec
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:reviewer:will-blair-bot
reviewable change id vpr_694eb9781b8b82ed
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_6a09c517baec09d7
→
vf_a7e84efcebc68fb7
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_a7e84efcebc68fb7
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_6a09c517baec09d7
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_6ac5c21b4e881d32
→
vf_3e548b0a1c8ee3b2
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_3e548b0a1c8ee3b2
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_6ac5c21b4e881d32
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_6b3b8f311ce880c3
→
vf_421b336a4bf3e428
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_421b336a4bf3e428
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_6b3b8f311ce880c3
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_6b51d32fbaec928f
→
vf_c8bc589dc291ef29
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_c8bc589dc291ef29
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_6b51d32fbaec928f
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_6b8854e339b1c47e
→
vf_c28fc03e98c273ae
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_c28fc03e98c273ae
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_6b8854e339b1c47e
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_6be8f4eb523fc85e
→
vf_ee518eccf5386826
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_ee518eccf5386826
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_6be8f4eb523fc85e
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.caveatcontestedreviewer:will-blair-bot2026-05-06
id
vpr_6c5189e1748f9542
→
vf_2e7192704f1767e4
Decision-console scope: ARIA/APOE4 risk is a stratification and monitoring constraint, not a standalone contraindication claim; interpret with current label criteria, MRI monitoring, anticoagulant context, and local eligibility rules.
contribution class
frontier change
applied
source and evidence
vf_2e7192704f1767e4
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_6c5189e1748f9542
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
evidence_atom.locator_repairunreviewedreviewer:will-blair2026-05-10
id
vpr_6dc4e4b4487257cb
→
vea_8f19ccc9718a7199
Wave A.1 mechanical curation: copy parent source locator to evidence atom; substantive DOI verification deferred to human pass.
contribution class
frontier change
applied
source and evidence
vea_8f19ccc9718a7199
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair
reviewable change id vpr_6dc4e4b4487257cb
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_6e41d9c50cee5b6f
→
vf_cc13f5d991f2c86c
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_cc13f5d991f2c86c
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_6e41d9c50cee5b6f
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_6e6b7991ca12d614
→
vf_9ded3333a52f3e58
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_9ded3333a52f3e58
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_6e6b7991ca12d614
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_6f700e042277aa81
→
vf_a74a1efa53aa4ed8
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_a74a1efa53aa4ed8
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_6f700e042277aa81
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_70123c2bf8afacd5
→
vf_d955b6b55732d153
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_d955b6b55732d153
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_70123c2bf8afacd5
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_7029395b74841f83
→
vf_a74a1efa53aa4ed8
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_a74a1efa53aa4ed8
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_7029395b74841f83
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_71c5acc1fba68227
→
vf_3f545ffd6b103146
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_3f545ffd6b103146
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_71c5acc1fba68227
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewagent:vela-curation-bot-2026-05-092026-05-09
id
vpr_72eb9a0673dbda13
→
vf_cc13f5d991f2c86c
Cardinal review of anti-Aβ MAb class as of 2023 covering aducanumab, lecanemab, donanemab. The class assertion is uncontested at scope: amyloid-removing MAbs do reduce plaque burden on PET imaging. Agent-drafted accept; eligible for human re-review.
contribution class
review
applied
source and evidence
vf_cc13f5d991f2c86c
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:vela-curation-bot-2026-05-09
reviewable change id vpr_72eb9a0673dbda13
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.caveatcontestedreviewer:will-blair-bot2026-05-06
id
vpr_7420a100feb4fe3f
→
vf_03875dbe6be66b00
BACE failures should not be treated as proof that every amyloid-lowering approach fails.
contribution class
frontier change
applied
source and evidence
vf_03875dbe6be66b00
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_7420a100feb4fe3f
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_76a4ee28cc03caef
→
vf_e075a3729ff31c8a
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_e075a3729ff31c8a
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_76a4ee28cc03caef
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:reviewer:will-blair-bot2026-05-06
id
vpr_79d1753a7e0994df
→
va_d369615d09f28cad
Import artifact clinicaltrials_gov_v2_NCT02484547 from artifact packet cap_818a078e8b9d8ed6
contribution class
source artifact
applied
source and evidence
va_d369615d09f28cad
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:reviewer:will-blair-bot
reviewable change id vpr_79d1753a7e0994df
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_7ad483428aa6f4fc
→
vf_dfadec272ade726c
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_dfadec272ade726c
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_7ad483428aa6f4fc
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_7af2e50631e9c97c
→
vf_2ac35ecfb0c1503a
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_2ac35ecfb0c1503a
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_7af2e50631e9c97c
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:reviewer:will-blair-bot2026-05-06
id
vpr_7cbdb92d91c7980a
→
va_f7a3b488793a0a01
Import artifact clinicaltrials_gov_v2_NCT05738486 from artifact packet cap_818a078e8b9d8ed6
contribution class
source artifact
applied
source and evidence
va_f7a3b488793a0a01
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:reviewer:will-blair-bot
reviewable change id vpr_7cbdb92d91c7980a
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.caveatcontestedreviewer:will-blair-bot2026-05-06
id
vpr_7cd889d1f403723b
→
vf_2e7192704f1767e4
Risk estimates should be read from current labels and trial safety tables before patient-level decisions.
contribution class
frontier change
applied
source and evidence
vf_2e7192704f1767e4
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_7cd889d1f403723b
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_7f6e63d3c7fa8766
→
vf_3b32d4abf4da2c70
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_3b32d4abf4da2c70
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_7f6e63d3c7fa8766
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_8114b0e17e92a084
→
vf_672632084731817f
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_672632084731817f
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_8114b0e17e92a084
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_811684123aeb6b25
→
vf_5d9f6c28e11aa258
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_5d9f6c28e11aa258
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_811684123aeb6b25
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.confidence_reviseunreviewedreviewer:will-blair-bot2026-05-06
id
vpr_816a9046d43fd5e2
→
vf_29671540d388fc5d
Decision-critical threshold deserves high review priority but is not itself a therapeutic effect.
contribution class
frontier change
applied
source and evidence
vf_29671540d388fc5d
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_816a9046d43fd5e2
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_81c389ba7649fe21
→
vf_3d380bcccbe5850e
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_3d380bcccbe5850e
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_81c389ba7649fe21
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_830a339c7aed097c
→
vf_7aaa7a87ea99e9e6
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_7aaa7a87ea99e9e6
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_830a339c7aed097c
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_85aed686019273ce
→
vf_b5b25525daef5712
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_b5b25525daef5712
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_85aed686019273ce
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.caveatcontestedreviewer:will-blair-bot2026-05-06
id
vpr_860cf1f1270c782d
→
vf_afddbeabc19efa09
Decision-console scope: biomarker movement supports target engagement and disease-biology interpretation, but the console keeps it separate from patient-level clinical benefit.
contribution class
frontier change
applied
source and evidence
vf_afddbeabc19efa09
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_860cf1f1270c782d
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_87af01a03b654c44
→
vf_243e224f30408563
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_243e224f30408563
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_87af01a03b654c44
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:reviewer:will-blair-bot2026-05-06
id
vpr_88b9bc484be8ef2b
→
va_590994a9dace874b
Import artifact regulatory_documents_v1_reg_fda_aducanumab from artifact packet cap_3648613e8c0d117f
contribution class
source artifact
applied
source and evidence
va_590994a9dace874b
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:reviewer:will-blair-bot
reviewable change id vpr_88b9bc484be8ef2b
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.entity_resolveunreviewedreviewer:will-blair2026-05-10
id
vpr_89fb94bdd3aee792
→
vf_155dd090fb7c6ff7
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
contribution class
frontier change
applied
source and evidence
vf_155dd090fb7c6ff7
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair
reviewable change id vpr_89fb94bdd3aee792
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:scienceclaw-demo2026-05-06
id
vpr_8c1348771aa0224b
→
va_3647a3a98c8f7ffb
Import artifact scaa_artifact_002 from artifact packet cap_9633575b0bead5b7
contribution class
source artifact
applied
source and evidence
va_3647a3a98c8f7ffb
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:scienceclaw-demo
reviewable change id vpr_8c1348771aa0224b
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.caveatcontestedreviewer:will-blair-bot2026-05-06
id
vpr_8e90fb565dce3ae1
→
vf_6aff53d375659bcf
This is a frontier-level pattern, not a per-patient surrogate validation statement.
contribution class
frontier change
applied
source and evidence
vf_6aff53d375659bcf
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_8e90fb565dce3ae1
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:scienceclaw-shaped-demo2026-05-06
id
vpr_8e92753ddd40f4f2
→
va_15b17e0f672c06cf
Import artifact sc_artifact_leqembi_safety from artifact packet cap_anti_amyloid_scienceclaw_demo
contribution class
source artifact
applied
source and evidence
va_15b17e0f672c06cf
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:scienceclaw-shaped-demo
reviewable change id vpr_8e92753ddd40f4f2
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_942ae202f8fa3144
→
vf_03875dbe6be66b00
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_03875dbe6be66b00
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_942ae202f8fa3144
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_942d5de98c77d839
→
vf_421b336a4bf3e428
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_421b336a4bf3e428
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_942d5de98c77d839
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_94b5a2a50c20656d
→
vf_5b5191d116e8c25a
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_5b5191d116e8c25a
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_94b5a2a50c20656d
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.confidence_reviseunreviewedreviewer:will-blair-bot2026-05-06
id
vpr_953ca8193cb056d3
→
vf_f738e7618b5339b8
Discordant phase 3 record lowers confidence in aducanumab as a stable translation anchor.
contribution class
frontier change
applied
source and evidence
vf_f738e7618b5339b8
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_953ca8193cb056d3
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_956043f85edcff38
→
vf_213d7b9c875676dc
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_213d7b9c875676dc
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_956043f85edcff38
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_96fd1f32bd8ff594
→
vf_afddbeabc19efa09
Reviewed for decision-console use: biomarker finding is explicitly separated from clinical-benefit claims.
contribution class
review
applied
source and evidence
vf_afddbeabc19efa09
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_96fd1f32bd8ff594
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_983f8e7e8f7075fe
→
vf_fab203251ba1c55f
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_fab203251ba1c55f
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_983f8e7e8f7075fe
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_986fcbec9db12008
→
vf_8bc2689859ba7334
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_8bc2689859ba7334
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_986fcbec9db12008
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_989a967e35a8669f
→
vf_00dd3d0421cb98d6
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_00dd3d0421cb98d6
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_989a967e35a8669f
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_99cb48432035a148
→
vf_492d3cfa2c3df2cd
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_492d3cfa2c3df2cd
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_99cb48432035a148
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_9a75f07b7f6b12ab
→
vf_b9abbfaac138a566
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_b9abbfaac138a566
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_9a75f07b7f6b12ab
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_9b41ea4d7c163448
→
vf_d42dc785b45dde84
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_d42dc785b45dde84
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_9b41ea4d7c163448
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_9d42728a1f18fb47
→
vf_f112dd973caf9328
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_f112dd973caf9328
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_9d42728a1f18fb47
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_9e8421af35d93d1e
→
vf_ce83dfe6fbe4c01d
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_ce83dfe6fbe4c01d
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_9e8421af35d93d1e
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_9ecc624628039a36
→
vf_ef2db88a81a37fcf
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_ef2db88a81a37fcf
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_9ecc624628039a36
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_9fbb9031837f58c3
→
vf_dc28e2c8084e9f8d
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_dc28e2c8084e9f8d
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_9fbb9031837f58c3
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_a128deb48e5f4186
→
vf_3ef6135eee626ee1
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_3ef6135eee626ee1
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_a128deb48e5f4186
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_a32b61d4ac00d7f5
→
vf_6e3f22f4cb7f83a5
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_6e3f22f4cb7f83a5
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_a32b61d4ac00d7f5
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_a4ac19f423ace79b
→
vf_73922f63fe4c2e7c
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_73922f63fe4c2e7c
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_a4ac19f423ace79b
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_a4ea3c0be15b6938
→
vf_dc28e2c8084e9f8d
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_dc28e2c8084e9f8d
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_a4ea3c0be15b6938
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_a7977d9dc4f404da
→
vf_2f9e150f3c70016b
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_2f9e150f3c70016b
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_a7977d9dc4f404da
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_a901f7375eedf9be
→
vf_247ab84f7a601b89
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_247ab84f7a601b89
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_a901f7375eedf9be
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.noteunreviewedagent:agent-discourse-demo2026-05-06
id
vpr_aa80b77e965acc0b
→
vf_3ef6135eee626ee1
Import external runtime review signal disc_review_001 from packet cap_c8affa0f8ff7273f
contribution class
frontier change
applied
source and evidence
vf_3ef6135eee626ee1
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:agent-discourse-demo
reviewable change id vpr_aa80b77e965acc0b
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:scienceclaw-shaped-demo2026-05-06
id
vpr_aba4854e34abc6c7
→
va_584e43ffa2fdd63c
Import artifact sc_artifact_clarity_registry from artifact packet cap_anti_amyloid_scienceclaw_demo
contribution class
source artifact
applied
source and evidence
va_584e43ffa2fdd63c
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:scienceclaw-shaped-demo
reviewable change id vpr_aba4854e34abc6c7
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.span_repairunreviewedreviewer:will-blair2026-05-10
id
vpr_ac0f8badc71a5eef
→
vf_5142fb9694998132
Wave A.3 curation: paraphrased span anchored to Bartels et al. Neurobiol Aging 2010 (age-related P-gp decline) and van Assema et al. Brain 2012 (P-gp dysfunction in AD review). Span is curator-paraphrased; cited paper sections are the load-bearing ones.
contribution class
frontier change
applied
source and evidence
vf_5142fb9694998132
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair
reviewable change id vpr_ac0f8badc71a5eef
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_ad06f341cb172836
→
vf_13d8e4a50ab060a0
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_13d8e4a50ab060a0
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_ad06f341cb172836
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_ad6728f8155d6c0c
→
vf_0bcf6cd07682db80
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_0bcf6cd07682db80
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_ad6728f8155d6c0c
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_ad88a20f3ac37c0d
→
vf_1ee3be6d4e3dbe33
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_1ee3be6d4e3dbe33
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_ad88a20f3ac37c0d
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:reviewer:will-blair-bot2026-05-06
id
vpr_b290bba0b704265f
→
va_504eaaa20a957f44
Import artifact clinicaltrials_gov_v2_NCT02245737 from artifact packet cap_818a078e8b9d8ed6
contribution class
source artifact
applied
source and evidence
va_504eaaa20a957f44
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:reviewer:will-blair-bot
reviewable change id vpr_b290bba0b704265f
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_b2e493c14551eee5
→
vf_15e91a7cbffb3d34
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_15e91a7cbffb3d34
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_b2e493c14551eee5
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.confidence_reviseunreviewedreviewer:will-blair-bot2026-05-06
id
vpr_b4d3f58f831da9f6
→
vf_56f893a9fe9651de
Small pilot evidence lowers translation confidence until replicated.
contribution class
frontier change
applied
source and evidence
vf_56f893a9fe9651de
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_b4d3f58f831da9f6
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_b5c3e00a41384900
→
vf_ceb7add1b9699180
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_ceb7add1b9699180
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_b5c3e00a41384900
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_b61bd5d4f01f67c8
→
vf_3ea4b6ad3a6a1bc9
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_3ea4b6ad3a6a1bc9
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_b61bd5d4f01f67c8
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_b647f9eb3df29808
→
vf_0973a3c4a839b774
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_0973a3c4a839b774
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_b647f9eb3df29808
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewagent:vela-curation-bot-2026-05-092026-05-09
id
vpr_b6c12523a67fe3e6
→
vf_a7e84efcebc68fb7
TRAILBLAZER-ALZ 4 head-to-head vs aducanumab demonstrated donanemab superiority on amyloid clearance at 6 months. Agent-drafted accept; eligible for human re-review.
contribution class
review
applied
source and evidence
vf_a7e84efcebc68fb7
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:vela-curation-bot-2026-05-09
reviewable change id vpr_b6c12523a67fe3e6
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.span_repairunreviewedreviewer:will-blair2026-05-10
id
vpr_b8c33960dfbbdc9f
→
vf_61249fb410ed2d52
Wave A.3 curation: paraphrased span anchored to Montagne et al., Nature 2020 (DOI 10.1038/s41586-020-2247-3) abstract and Figures 1-2 main findings. Span is curator-paraphrased not direct-quoted; the cited sections are the load-bearing ones for the assertion.
contribution class
frontier change
applied
source and evidence
vf_61249fb410ed2d52
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair
reviewable change id vpr_b8c33960dfbbdc9f
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewagent:vela-curation-bot-2026-05-092026-05-09
id
vpr_bc40e0ba80773b34
→
vf_3ef6135eee626ee1
ARIA (amyloid-related imaging abnormalities) including edema (ARIA-E) and hemosiderin (ARIA-H) is a well-established class effect of anti-Aβ antibodies, especially in APOE4 homozygotes. Agent-drafted accept; eligible for human re-review.
contribution class
review
applied
source and evidence
vf_3ef6135eee626ee1
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:vela-curation-bot-2026-05-09
reviewable change id vpr_bc40e0ba80773b34
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_bc4de8a082407abf
→
vf_efad6b4cb4927b3a
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_efad6b4cb4927b3a
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_bc4de8a082407abf
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:reviewer:will-blair-bot2026-05-06
id
vpr_bd850433208c0a6e
→
va_cf309b1b0dfa560e
Import artifact sir_4c5bbc2d54bb56be_manifest from artifact packet cap_3648613e8c0d117f
contribution class
source artifact
applied
source and evidence
va_cf309b1b0dfa560e
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:reviewer:will-blair-bot
reviewable change id vpr_bd850433208c0a6e
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
evidence_atom.locator_repairunreviewedreviewer:will-blair2026-05-10
id
vpr_be998bec89553a72
→
vea_425a112a4b09fa12
Wave A.1 mechanical curation: copy parent source locator to evidence atom; substantive DOI verification deferred to human pass.
contribution class
frontier change
applied
source and evidence
vea_425a112a4b09fa12
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair
reviewable change id vpr_be998bec89553a72
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_bffa54a1b9fb7c27
→
vf_6aff53d375659bcf
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_6aff53d375659bcf
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_bffa54a1b9fb7c27
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedagent:bbb-curation-bot-2026-05-092026-05-09
id
vpr_c066c6886d42f094
→
vf_61249fb410ed2d52
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_61249fb410ed2d52
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:bbb-curation-bot-2026-05-09
reviewable change id vpr_c066c6886d42f094
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_c165a37b0cf53a3b
→
vf_2e7192704f1767e4
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_2e7192704f1767e4
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_c165a37b0cf53a3b
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_c224ecf21fc65b49
→
vf_243e224f30408563
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_243e224f30408563
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_c224ecf21fc65b49
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_c2cfd6d2b19bebdc
→
vf_9ded3333a52f3e58
Reviewed for decision-console use: bounded CLARITY AD benefit claim with explicit early symptomatic population, amyloid-confirmed scope, endpoint, and risk caveat.
contribution class
review
applied
source and evidence
vf_9ded3333a52f3e58
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_c2cfd6d2b19bebdc
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:scienceclaw-shaped-demo2026-05-06
id
vpr_c2f6221d868d820a
→
va_861de5595c5679f1
Import artifact sc_artifact_cms_coverage from artifact packet cap_anti_amyloid_scienceclaw_demo
contribution class
source artifact
applied
source and evidence
va_861de5595c5679f1
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:scienceclaw-shaped-demo
reviewable change id vpr_c2f6221d868d820a
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_c364b1217f9e0809
→
vf_b57db3f4185a8353
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_b57db3f4185a8353
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_c364b1217f9e0809
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.span_repairunreviewedreviewer:will-blair2026-05-10
id
vpr_c43731aea1eb7545
→
vf_155dd090fb7c6ff7
Wave A.3 curation: paraphrased span anchored to Yamazaki et al. Brain 2019 (tight-junction loss in AD post-mortem) and Carrano et al. Antioxid Redox Signal 2011 (oxidative-stress-mediated BBB tight-junction breakdown). Span is curator-paraphrased; cited paper sections are the load-bearing ones.
contribution class
frontier change
applied
source and evidence
vf_155dd090fb7c6ff7
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair
reviewable change id vpr_c43731aea1eb7545
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_c52c545b2fae2cbc
→
vf_e075a3729ff31c8a
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_e075a3729ff31c8a
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_c52c545b2fae2cbc
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.confidence_reviseunreviewedreviewer:will-blair-bot2026-05-06
id
vpr_c6716e8617594005
→
vf_4f57348016eea37b
Preclinical delivery improvement does not rescue failed clinical BACE programs.
contribution class
frontier change
applied
source and evidence
vf_4f57348016eea37b
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_c6716e8617594005
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_c6a2ef99f997e34a
→
vf_08887f653748dc78
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_08887f653748dc78
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_c6a2ef99f997e34a
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_c948a1e5d0a38746
→
vf_b10935043fb06532
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_b10935043fb06532
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_c948a1e5d0a38746
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_ccc97ca5ce161801
→
vf_f738e7618b5339b8
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_f738e7618b5339b8
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_ccc97ca5ce161801
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_ce963a3d74623bc2
→
vf_65b0b865df8bb87b
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_65b0b865df8bb87b
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_ce963a3d74623bc2
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:reviewer:will-blair-bot2026-05-06
id
vpr_cec2be34a6249569
→
va_bbd4c17750aa3b79
Import artifact clinicaltrials_gov_v2_NCT02008357 from artifact packet cap_818a078e8b9d8ed6
contribution class
source artifact
applied
source and evidence
va_bbd4c17750aa3b79
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:reviewer:will-blair-bot
reviewable change id vpr_cec2be34a6249569
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
artifact.assertacceptedagent:reviewer:will-blair-bot2026-05-06
id
vpr_cf33103a58ad222c
→
va_a6590d0640aa9b74
Import artifact clinicaltrials_gov_v2_NCT01953601 from artifact packet cap_818a078e8b9d8ed6
contribution class
source artifact
applied
source and evidence
va_a6590d0640aa9b74
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:reviewer:will-blair-bot
reviewable change id vpr_cf33103a58ad222c
review contract
artifact gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_d01beb316786f3bd
→
vf_08c81dd507f6a047
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_08c81dd507f6a047
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_d01beb316786f3bd
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
evidence_atom.locator_repairunreviewedreviewer:will-blair2026-05-10
id
vpr_d1458c25977cc36f
→
vea_25118d0d51e7bb38
Wave A.1 mechanical curation: copy parent source locator to evidence atom; substantive DOI verification deferred to human pass.
contribution class
frontier change
applied
source and evidence
vea_25118d0d51e7bb38
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair
reviewable change id vpr_d1458c25977cc36f
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_d3720ee76d36eed1
→
vf_3d75299a343a2fc8
Reviewed as safety-driven translation tension.
contribution class
review
applied
source and evidence
vf_3d75299a343a2fc8
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_d3720ee76d36eed1
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_d86065fcd5f2931e
→
vf_5b5191d116e8c25a
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_5b5191d116e8c25a
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_d86065fcd5f2931e
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.caveatcontestedreviewer:will-blair-bot2026-05-06
id
vpr_d9ec6f23226ebc44
→
vf_7b4bfdf919b22af5
Tau-selection criteria affect generalization to broader clinical populations.
contribution class
frontier change
applied
source and evidence
vf_7b4bfdf919b22af5
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_d9ec6f23226ebc44
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_da34872d64ddd2c9
→
vf_03875dbe6be66b00
Reviewed as amyloid-pathway translation tension, not as a direct antibody contradiction.
contribution class
review
applied
source and evidence
vf_03875dbe6be66b00
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_da34872d64ddd2c9
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_da391ee0b3c02122
→
vf_49c7ced6d7804989
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_49c7ced6d7804989
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_da391ee0b3c02122
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_da690b1206e41f7f
→
vf_2b10fee64b9970af
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_2b10fee64b9970af
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_da690b1206e41f7f
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.caveatcontestedreviewer:will-blair-bot2026-05-06
id
vpr_db2247814be42ec2
→
vf_9ded3333a52f3e58
Decision-console scope: this finding supports bounded early symptomatic antibody benefit, not a class-wide or patient-level treatment recommendation; the absolute CDR-SB effect should be interpreted with ARIA risk, APOE4 status, stage, and meaningfulness thresholds.
contribution class
frontier change
applied
source and evidence
vf_9ded3333a52f3e58
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_db2247814be42ec2
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_dbe3937ef6b89a41
→
vf_e46485c320b6b4ff
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
contribution class
review
applied
source and evidence
vf_e46485c320b6b4ff
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_dbe3937ef6b89a41
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_dcfc49f1d3d56d1d
→
vf_c0ab26a1a6a29290
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_c0ab26a1a6a29290
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_dcfc49f1d3d56d1d
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_dffe6d92371fa2d5
→
vf_bef33326792f5c60
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_bef33326792f5c60
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_dffe6d92371fa2d5
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_e242b8fa10d4df8c
→
vf_4d8aa40cc734ab93
Regulatory history is factual, but its implication for the anti-amyloid class remains contested.
contribution class
review
applied
source and evidence
vf_4d8aa40cc734ab93
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_e242b8fa10d4df8c
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_e2db719be2de54a8
→
vf_b49cc3f708a871f2
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_b49cc3f708a871f2
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_e2db719be2de54a8
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_e368f288357811a5
→
vf_aa236af8df84fd0d
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_aa236af8df84fd0d
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_e368f288357811a5
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_e3c0593e815b03da
→
vf_26a520047b5ea505
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_26a520047b5ea505
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_e3c0593e815b03da
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_e3c239ed2447881a
→
vf_cfdbca8b2a4aa0cf
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_cfdbca8b2a4aa0cf
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_e3c239ed2447881a
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_e4f79d0b4069b697
→
vf_29671540d388fc5d
Reviewed for decision-console use: endpoint meaningfulness finding is retained as an explicit interpretation tension rather than smoothed into the benefit answer.
contribution class
review
applied
source and evidence
vf_29671540d388fc5d
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_e4f79d0b4069b697
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.entity_resolveunreviewedreviewer:will-blair2026-05-10
id
vpr_e5eea05eb19c53ab
→
vf_5142fb9694998132
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
contribution class
frontier change
applied
source and evidence
vf_5142fb9694998132
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair
reviewable change id vpr_e5eea05eb19c53ab
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_e6c4dc001a7dbad6
→
vf_994f2bcb18f2aeeb
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_994f2bcb18f2aeeb
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_e6c4dc001a7dbad6
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_e7381a0a590bfec1
→
vf_6e3f22f4cb7f83a5
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_6e3f22f4cb7f83a5
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_e7381a0a590bfec1
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_e799b67d3197c6fb
→
vf_78e8d7300689c72f
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_78e8d7300689c72f
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_e799b67d3197c6fb
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_e7b9a755f3ef54f9
→
vf_b6573124f68cc5f0
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_b6573124f68cc5f0
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_e7b9a755f3ef54f9
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewagent:vela-curation-bot-2026-05-092026-05-09
id
vpr_e83c66174a4cda3e
→
vf_fab203251ba1c55f
Lecanemab CLARITY-AD pivotal trial published NEJM 2023 (Van Dyck et al.) demonstrated 27% slowing of decline vs placebo over 18 months. AHEAD 3-45 substudy follow-up data is consistent. Agent-drafted accept; eligible for human re-review.
contribution class
review
applied
source and evidence
vf_fab203251ba1c55f
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:vela-curation-bot-2026-05-09
reviewable change id vpr_e83c66174a4cda3e
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_e97bf809147407f5
→
vf_8a341b9535bd5ba4
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_8a341b9535bd5ba4
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_e97bf809147407f5
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_eb109c0f591f33b4
→
vf_de9cbca0f1e77165
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_de9cbca0f1e77165
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_eb109c0f591f33b4
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_eb5bb753c55ac69c
→
vf_806ac99cdbc7ad59
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_806ac99cdbc7ad59
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_eb5bb753c55ac69c
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_ebec765bdd0348ba
→
vf_61168d24f5a8aa3c
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_61168d24f5a8aa3c
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_ebec765bdd0348ba
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_ebfe1e1a4462f642
→
vf_43801773d5de283b
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_43801773d5de283b
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_ebfe1e1a4462f642
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_ec4108d02b60d3dc
→
vf_1e974fb24f241002
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_1e974fb24f241002
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_ec4108d02b60d3dc
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_f07704c845e9e7de
→
vf_03aac0ab77ae80e8
Reviewed as a stage and target-form tension against positive antibody programs.
contribution class
review
applied
source and evidence
vf_03aac0ab77ae80e8
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_f07704c845e9e7de
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_f18679f7c1f13c31
→
vf_4f57348016eea37b
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_4f57348016eea37b
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_f18679f7c1f13c31
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_f1dd2d20ad25c592
→
vf_2f5a87e11029cdff
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_2f5a87e11029cdff
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_f1dd2d20ad25c592
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_f2b468ec2f316fdf
→
vf_75102bc7f536a410
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_75102bc7f536a410
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_f2b468ec2f316fdf
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_f2cafc20a300898a
→
vf_cc9497a6f7ca73ec
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_cc9497a6f7ca73ec
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_f2cafc20a300898a
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_f3a6eed6c7cf8978
→
vf_e2554d6d7ec32686
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_e2554d6d7ec32686
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_f3a6eed6c7cf8978
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_f5b2748e2617fab1
→
vf_a5298f57298ae556
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_a5298f57298ae556
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_f5b2748e2617fab1
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_f64b0986f3496c6d
→
vf_3b12a393033157ba
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_3b12a393033157ba
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_f64b0986f3496c6d
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_f665d8023056c5fd
→
vf_3d75299a343a2fc8
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_3d75299a343a2fc8
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_f665d8023056c5fd
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_f69ec8a1efd7332f
→
vf_0a324df7bbc35ac3
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_0a324df7bbc35ac3
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_f69ec8a1efd7332f
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_f7550e4e597570f8
→
vf_ee518eccf5386826
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_ee518eccf5386826
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_f7550e4e597570f8
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewreviewer:will-blair-bot2026-05-06
id
vpr_fafdaa824809d62d
→
vf_0767356cc73a6387
Reviewed as BACE class tension against broad amyloid-lowering optimism.
contribution class
review
applied
source and evidence
vf_0767356cc73a6387
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_fafdaa824809d62d
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_fb13d9c46980221c
→
vf_b299e3ad7965e4d7
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_b299e3ad7965e4d7
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_fb13d9c46980221c
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_fc22e43324d406a7
→
vf_45b4e018839586ea
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_45b4e018839586ea
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_fc22e43324d406a7
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.noteunreviewedagent:agent-discourse-demo2026-05-06
id
vpr_fc7f39e9a840b6b5
→
vf_3ef6135eee626ee1
Import external runtime review signal disc_comment_001 from packet cap_c8affa0f8ff7273f
contribution class
frontier change
applied
source and evidence
vf_3ef6135eee626ee1
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:agent-discourse-demo
reviewable change id vpr_fc7f39e9a840b6b5
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.reviewunder reviewagent:vela-curation-bot-2026-05-092026-05-09
id
vpr_fe1facc0dc7a30c2
→
vf_98bca71097f11704
TRAILBLAZER-ALZ Phase II (Mintun et al., NEJM 2021) was the foundational signal that donanemab clears amyloid plaques. Agent-drafted accept; eligible for human re-review.
contribution class
review
applied
source and evidence
vf_98bca71097f11704
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:vela-curation-bot-2026-05-09
reviewable change id vpr_fe1facc0dc7a30c2
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_fe5141c34390f678
→
vf_7b7a150ec0cc7288
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_7b7a150ec0cc7288
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_fe5141c34390f678
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedreviewer:will-blair-bot2026-05-06
id
vpr_ffed79d358f0b4ed
→
vf_003831db954a151c
Manual finding added to frontier state
contribution class
extraction
applied
source and evidence
vf_003831db954a151c
The source handle stays candidate material until review accepts it.
engine context
drafted by reviewer:will-blair-bot
reviewable change id vpr_ffed79d358f0b4ed
review contract
reviewer gate
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →

Resolved · 4

finding.addproposedagent:scienceclaw-shaped-demo2026-05-06
id
vpr_4deb2d49c543abc0
→
vf_215f1511b984ae71
Open need sc_need_patient_level_dataset imported from artifact packet cap_anti_amyloid_scienceclaw_demo
contribution class
extraction
rejected
source and evidence
vf_215f1511b984ae71
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:scienceclaw-shaped-demo
reviewable change id vpr_4deb2d49c543abc0
review contract
rejected event
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedagent:agent-discourse-demo2026-05-06
id
vpr_799927d808600296
→
vf_dd4cafca257ada09
Candidate claim claim_disc_post_001 imported from artifact packet cap_c8affa0f8ff7273f
contribution class
extraction
rejected
source and evidence
vf_dd4cafca257ada09
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:agent-discourse-demo
reviewable change id vpr_799927d808600296
review contract
rejected event
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedagent:scienceclaw-demo2026-05-06
id
vpr_cd5511a971df87f5
→
vf_294dc3cbdbddfaa4
Candidate claim claim_002 imported from artifact packet cap_9633575b0bead5b7
contribution class
extraction
rejected
source and evidence
vf_294dc3cbdbddfaa4
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:scienceclaw-demo
reviewable change id vpr_cd5511a971df87f5
review contract
rejected event
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →
finding.addproposedagent:scienceclaw-shaped-demo2026-05-06
id
vpr_e7c9655ce36f4e18
→
vf_b14b0177eb30efbb
Candidate claim sc_claim_agent_artifacts_are_source_material imported from artifact packet cap_anti_amyloid_scienceclaw_demo
contribution class
extraction
rejected
source and evidence
vf_b14b0177eb30efbb
The source handle stays candidate material until review accepts it.
engine context
drafted by agent:scienceclaw-shaped-demo
reviewable change id vpr_e7c9655ce36f4e18
review contract
rejected event
Preview the state effect before accepting the event.
proof effect
preview pending
Open the preview to see affected state.
inspect this change →

Search Canopus

A source or target enters

An attempt packet is produced

A record change is drafted

Checks inspect the change

A review event decides

Proof and maps update

Change request

Diff packet

Check output

Reviewer decision

Accepted event