frontiers / frontier
Reviewable change
back to reviewP-glycoprotein expression at the blood-brain barrier declines with age and is further reduced in Alzheimer's disease, contributing to amyloid-beta accumulation by impaired cerebral efflux; this is the same transporter that excludes most oncology drugs from glioblastoma at the infiltrative margin.
This is a proposal, not yet accepted frontier state. It names what it would change and who proposed it. Only an accepted review event, signed under reviewer authority, writes it into the frontier. Until then it carries no authority over the record.
Proposed change
reason
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings. Amyloid-beta is the cleavage product of APP; the UniProt entry P05067 is the canonical anchor for the parent protein and the standard reference for amyloid-beta peptide research.
Provenance
proposed by
reviewer:will-blair
actor type
human
created at
2026-05-10
target type
finding
Affected finding
inspect finding →P-glycoprotein expression at the blood-brain barrier declines with age and is further reduced in Alzheimer's disease, contributing to amyloid-beta accumulation by impaired cerebral efflux; this is the same transporter that excludes most oncology drugs from glioblastoma at the infiltrative margin.
vf_5142fb9694998132The diff is computed against current frontier state, the same diff a reviewer reads before deciding.
The live diff is computed from a writable workspace. This frontier is read-only here, so the change is shown as recorded without a recomputed before / after.
Canopus treats material changes like reviewable requests: one bounded packet, check output, reviewer decision, and accepted frontier effect.
Anti-amyloid translation in Alzheimer's disease receives a reviewable source, finding, caveat, replication, evaluation, or proof-affecting edit.
The packet names affected record objects, evidence, rationale, reviewer-facing fields, and expected proof impact.
Schema, provenance, benchmark, contradiction, and proof checks decide whether the request is ready to read.
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