Proposed change
reason
TRAILBLAZER-ALZ 4 head-to-head vs aducanumab demonstrated donanemab superiority on amyloid clearance at 6 months. Agent-drafted accept; eligible for human re-review.
frontiers / frontier
Reviewable change
back to reviewDonanemab in TRAILBLAZER-ALZ 4 demonstrates that early tau burden (low/medium tau PET) selects for greater clinical benefit; donanemab-treated participants with low/medium tau showed 35% slower iADRS decline vs. placebo at 18 months, underscoring importance of biomarker-based patient selection.
This is a proposal, not yet accepted frontier state. It names what it would change and who proposed it. Only an accepted review event, signed under reviewer authority, writes it into the frontier. Until then it carries no authority over the record.
Proposed change
reason
TRAILBLAZER-ALZ 4 head-to-head vs aducanumab demonstrated donanemab superiority on amyloid clearance at 6 months. Agent-drafted accept; eligible for human re-review.
Provenance
proposed by
agent:vela-curation-bot-2026-05-09
actor type
human
created at
2026-05-09
target type
finding
Affected finding
inspect finding →Donanemab in TRAILBLAZER-ALZ 4 demonstrates that early tau burden (low/medium tau PET) selects for greater clinical benefit; donanemab-treated participants with low/medium tau showed 35% slower iADRS decline vs. placebo at 18 months, underscoring importance of biomarker-based patient selection.
vf_a7e84efcebc68fb7The diff is computed against current frontier state, the same diff a reviewer reads before deciding.
The live diff is computed from a writable workspace. This frontier is read-only here, so the change is shown as recorded without a recomputed before / after.
Canopus treats material changes like reviewable requests: one bounded packet, check output, reviewer decision, and accepted frontier effect.
Anti-amyloid translation in Alzheimer's disease receives a reviewable source, finding, caveat, replication, evaluation, or proof-affecting edit.
The packet names affected record objects, evidence, rationale, reviewer-facing fields, and expected proof impact.
Schema, provenance, benchmark, contradiction, and proof checks decide whether the request is ready to read.
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Only the accepted event mutates frontier state. Atlases, constellations, and search update from that record state.