frontiers / frontier
Reviewable change
back to reviewPericyte loss in cognitive-impairment-prone hippocampal regions precedes blood-brain barrier breakdown and is detectable before clinical Alzheimer disease symptom onset; this provides a timing-window for biomarker-driven intervention.
This is a proposal, not yet accepted frontier state. It names what it would change and who proposed it. Only an accepted review event, signed under reviewer authority, writes it into the frontier. Until then it carries no authority over the record.
Proposed change
reason
Wave A.3 curation: paraphrased span anchored to Montagne et al., Nature 2020 (DOI 10.1038/s41586-020-2247-3) abstract and Figures 1-2 main findings. Span is curator-paraphrased not direct-quoted; the cited sections are the load-bearing ones for the assertion.
Provenance
proposed by
reviewer:will-blair
actor type
human
created at
2026-05-10
target type
finding
Affected finding
inspect finding →Pericyte loss in cognitive-impairment-prone hippocampal regions precedes blood-brain barrier breakdown and is detectable before clinical Alzheimer disease symptom onset; this provides a timing-window for biomarker-driven intervention.
vf_61249fb410ed2d52The diff is computed against current frontier state, the same diff a reviewer reads before deciding.
The live diff is computed from a writable workspace. This frontier is read-only here, so the change is shown as recorded without a recomputed before / after.
Canopus treats material changes like reviewable requests: one bounded packet, check output, reviewer decision, and accepted frontier effect.
Anti-amyloid translation in Alzheimer's disease receives a reviewable source, finding, caveat, replication, evaluation, or proof-affecting edit.
The packet names affected record objects, evidence, rationale, reviewer-facing fields, and expected proof impact.
Schema, provenance, benchmark, contradiction, and proof checks decide whether the request is ready to read.
A steward accepts, rejects, caveats, revises, or retracts the request under an inspectable identity.
Only the accepted event mutates frontier state. Atlases, constellations, and search update from that record state.