evidence boundary
supportsobservational
An evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
frontiers / frontier
Evidence atom
back to sourcesevidence boundary
supportsAn evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
finding binding
boundMerck patent on iminothiadiazine dioxide scaffold BACE inhibitors encompassing the verubecestat (MK-8931) compound class; covers C2-ring-substituted variants of the thiadiazinane core used in the EPOCH and APECS Phase 3 trials.
inspect finding →
source binding
source-boundvs_5588c5efb07284af
inspect source →
review context
unverified2 reviewable changes and 0 evaluation records target this atom or its bound objects.
Evidence statement
Merck patent on iminothiadiazine dioxide scaffold BACE inhibitors encompassing the verubecestat (MK-8931) compound class; covers C2-ring-substituted variants of the thiadiazinane core used in the EPOCH and APECS Phase 3 trials.
locator
source:US9447085B2 — Iminothiadiazine dioxides containing a thioamide, amidine, or amide oxime group as BACE inhibitors, compositions, and their use (assignee: Merck Sharp and Dohme LLC) — Represents Merck's commercial IP position on the BACE1 inhibitor scaffold that dominated AD drug development 2012–2018; Phase 3 failure of verubecestat established that BACE inhibition at symptomatic stage is insufficient, reorienting the field toward earlier intervention and combination strategies.|section:curator_source
extraction method
manual_curation
support relation
supports
condition refs
vcnd_30b6fbe7f6e7401f
Caveats
No evidence-specific caveats are recorded.
events
vev_945fd8fbbaac1b39finding.reviewedAccepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
reviewer:will-blair-bot · 2026-05-06
vev_df20b2cdc051c871finding.assertedManual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
reviewable changes
vpr_6f700e042277aa81finding.addManual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
vpr_7029395b74841f83finding.reviewAccepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
applied · reviewer:will-blair-bot · 2026-05-06
evaluations
No evaluation rows are attached.