evidence boundary
supportsobservational
An evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
frontiers / frontier
Evidence atom
back to sourcesevidence boundary
supportsAn evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
finding binding
boundField consensus 2018-2022 shifted from soluble-Aβ targeting (solanezumab class) to aggregated-Aβ + protofibril targeting (lecanemab, donanemab, aducanumab); EXPEDITION3 read as definitive evidence that soluble Aβ is downstream marker not therapeutic substrate.
inspect finding →
source binding
source-boundvs_c06a1be73809d6e0
inspect source →
review context
unverified2 reviewable changes and 0 evaluation records target this atom or its bound objects.
Evidence statement
Field consensus 2018-2022 shifted from soluble-Aβ targeting (solanezumab class) to aggregated-Aβ + protofibril targeting (lecanemab, donanemab, aducanumab); EXPEDITION3 read as definitive evidence that soluble Aβ is downstream marker not therapeutic substrate.
locator
source:Cascade-densification deposit: Solanezumab EXPEDITION3 failure (Honig 2018) → broader anti-Aβ MAb scope refinement|section:curator_source
extraction method
manual_curation
support relation
supports
condition refs
vcnd_ba5af359e6fbac9e
Caveats
No evidence-specific caveats are recorded.
events
vev_0bb55211bc66258dfinding.assertedManual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
vev_66d0f35c86c36f5cfinding.reviewedAccepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
reviewer:will-blair-bot · 2026-05-06
reviewable changes
vpr_1cdb7be6b81b9c26finding.reviewAccepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
applied · reviewer:will-blair-bot · 2026-05-06
vpr_243c0195a9f529aefinding.addManual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
evaluations
No evaluation rows are attached.