evidence boundary
supportsobservational
An evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
frontiers / frontier
Evidence atom
back to sourcesevidence boundary
supportsAn evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
finding binding
boundDIAN-TU solanezumab arm (dominantly inherited AD prevention) terminated for futility 2020; soluble-Aβ-targeting MAb framework not viable in preclinical AD even in fully penetrant genetic risk.
inspect finding →
source binding
source-boundvs_c06a1be73809d6e0
inspect source →
review context
unverified2 reviewable changes and 0 evaluation records target this atom or its bound objects.
Evidence statement
DIAN-TU solanezumab arm (dominantly inherited AD prevention) terminated for futility 2020; soluble-Aβ-targeting MAb framework not viable in preclinical AD even in fully penetrant genetic risk.
locator
source:Cascade-densification deposit: Solanezumab EXPEDITION3 failure (Honig 2018) → broader anti-Aβ MAb scope refinement|section:curator_source
extraction method
manual_curation
support relation
supports
condition refs
vcnd_4300b53fe3aa9b99
Caveats
No evidence-specific caveats are recorded.
events
vev_5aca213c84a622a9finding.reviewedAccepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
reviewer:will-blair-bot · 2026-05-06
vev_cbd0279e6a68f029finding.assertedManual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
reviewable changes
vpr_19efd08ab5224ffcfinding.reviewAccepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
applied · reviewer:will-blair-bot · 2026-05-06
vpr_572854aaebd2536ffinding.addManual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
evaluations
No evaluation rows are attached.