record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to stateno incoming links yet
record state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding type[object Object] · [object Object] · [object Object] · [object Object]
evidence
source-boundexperimental · manual state transition; control details require source inspection · source-reported model organism
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition; control details require source inspection
evidence type
experimental
species
source-reported model organism
evidence spans
The Brain Shuttle version of an anti-Aβ antibody, utilizing a monovalent binding mode to the transferrin receptor (TfR), increases β-Amyloid target engagement in an Alzheimer's disease mouse model by 55-fold compared to the parent antibody.
Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle. · curator_source · 10.1016/j.neuron.2013.10.061
conditions
Provenance
source title
Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle.
doi
10.1016/j.neuron.2013.10.061
pmid
24411731
journal
Neuron
authors
Niewoehner J, Bohrmann B, Collin L, Urich E, Sade H, Maier P, Rueger P, Stracke JO
The Brain Shuttle version of an anti-Aβ antibody, utilizing a monovalent binding mode to the transferrin receptor (TfR), increases β-Amyloid target engagement in an Alzheimer's disease mouse model by 55-fold compared to the parent antibody.
vs_cc0b0e87713f429b · source:Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle.|section:curator_source · manual_curation
outgoing
No outgoing links.
incoming
No incoming links.
events
vev_2d600dd2c6d8a3c8finding.assertedManual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
reviewable changes
vpr_d01beb316786f3bdfinding.addManual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
evaluations
No evaluation record targets this finding id.