record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
accepted
frontiers / frontier
Finding bundle
back to stateno incoming links yet
record state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding type[object Object] · [object Object] · [object Object] · [object Object] · [object Object] · [object Object] · [object Object]
evidence
source-boundobservational · manual state transition; placebo-controlled clinical trial where source reports control arm · Homo sapiens
proof impact
packet context4 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition; placebo-controlled clinical trial where source reports control arm
evidence type
observational
species
Homo sapiens
evidence spans
Anti-amyloid immunotherapy ARIA (amyloid-related imaging abnormalities) — edema (ARIA-E) and microhemorrhage (ARIA-H) — occurs in 15-40% of APOE4 carriers receiving high-dose anti-Aβ antibodies; radiological characterization and risk stratification framework published to guide clinical management.
. . doi:10.1038/s41591-021-01319-w · curator_source · 10.1038/s41591-021-01319-w
conditions
Provenance
source title
. . doi:10.1038/s41591-021-01319-w
doi
10.1038/s41591-021-01319-w
authors
reviewer:will-blair-bot
Anti-amyloid immunotherapy ARIA (amyloid-related imaging abnormalities) — edema (ARIA-E) and microhemorrhage (ARIA-H) — occurs in 15-40% of APOE4 carriers receiving high-dose anti-Aβ antibodies; radiological characterization and risk stratification framework published to guide clinical management.
vs_6319aadf85c01c8f · source:. . doi:10.1038/s41591-021-01319-w|section:curator_source · manual_curation
outgoing
No outgoing links.
incoming
No incoming links.
events
vev_16fd2ce15417577ffinding.assertedManual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
vev_275b9104a902a559finding.reviewedARIA (amyloid-related imaging abnormalities) including edema (ARIA-E) and hemosiderin (ARIA-H) is a well-established class effect of anti-Aβ antibodies, especially in APOE4 homozygotes. Agent-drafted accept; eligible for human re-review.
agent:vela-curation-bot-2026-05-09 · 2026-05-09
vev_5c223679f7b07b17finding.notedExternal runtime review disc_review_001 on disc_post_001 recorded decision 'needs_revision': The review accepts the relevance of the source trail but rejects automatic promotion of the discourse claim until a Vela reviewer checks scope and source artifacts.. Treat this as review signal until a Vela reviewer accepts a state transition.
reviewer:will-blair-bot · 2026-05-06
vev_c58f15a88eddd977finding.notedExternal runtime comment disc_comment_001 on disc_post_001: Reviewer signal: attach the discourse post to ARIA/APOE4 risk narrowing, but do not let discourse confidence replace label, protocol, or trial evidence.. Treat this as review signal until a Vela reviewer accepts a state transition.
reviewer:will-blair-bot · 2026-05-06
reviewable changes
vpr_a128deb48e5f4186finding.addManual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
vpr_aa80b77e965acc0bfinding.noteImport external runtime review signal disc_review_001 from packet cap_c8affa0f8ff7273f
applied · agent:agent-discourse-demo · 2026-05-06
vpr_bc40e0ba80773b34finding.reviewARIA (amyloid-related imaging abnormalities) including edema (ARIA-E) and hemosiderin (ARIA-H) is a well-established class effect of anti-Aβ antibodies, especially in APOE4 homozygotes. Agent-drafted accept; eligible for human re-review.
applied · agent:vela-curation-bot-2026-05-09 · 2026-05-09
vpr_fc7f39e9a840b6b5finding.noteImport external runtime review signal disc_comment_001 from packet cap_c8affa0f8ff7273f
applied · agent:agent-discourse-demo · 2026-05-06
evaluations
No evaluation record targets this finding id.