source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable2 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
external sourcelocator
doi:10.1056/NEJMoa2301247
doi
10.1056/NEJMoa2301247
imported
2026-05-06T03:57:47.568674+00:00
extraction mode
manual_curation
authors
reviewer:will-blair-bot
Caveats
No source-specific caveats are recorded.
therapeutic · vf_a7e84efcebc68fb7
Donanemab in TRAILBLAZER-ALZ 4 demonstrates that early tau burden (low/medium tau PET) selects for greater clinical benefit; donanemab-treated participants with low/medium tau showed 35% slower iADRS decline vs. placebo at 18 months, underscoring importance of biomarker-based patient selection.
events
vev_c024b0951a1e22f7finding.assertedManual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
vev_f7d85b7113600040finding.reviewedTRAILBLAZER-ALZ 4 head-to-head vs aducanumab demonstrated donanemab superiority on amyloid clearance at 6 months. Agent-drafted accept; eligible for human re-review.
agent:vela-curation-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_6a09c517baec09d7finding.addManual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
vpr_b6c12523a67fe3e6finding.reviewTRAILBLAZER-ALZ 4 head-to-head vs aducanumab demonstrated donanemab superiority on amyloid clearance at 6 months. Agent-drafted accept; eligible for human re-review.
applied · agent:vela-curation-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation rows are attached.