source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
external sourcelocator
doi:10.1001/jamaneurol.2016.5076
doi
10.1001/jamaneurol.2016.5076
imported
2026-05-06T03:57:52.279610+00:00
extraction mode
manual_curation
authors
reviewer:will-blair-bot
Caveats
No source-specific caveats are recorded.
Gantenerumab subcutaneous dosing reduces brain amyloid in prodromal AD in a dose-dependent manner; a Phase II extension study demonstrated near-complete amyloid clearance at higher doses, informing the dose selection for the Phase III trials.
events
vev_080ad2b24c0467definding.assertedManual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
reviewable changes
vpr_dcfc49f1d3d56d1dfinding.addManual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
evaluations
No evaluation rows are attached.