source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:Le et al. Science 2017; Marabelle et al. J Clin Oncol 2020 (KEYNOTE-158)
imported
2026-05-09T22:24:01.704434+00:00
extraction mode
manual_curation
authors
agent:immuno-research-bot-2026-05-09
Caveats
No source-specific caveats are recorded.
Microsatellite instability (MSI-H) and mismatch-repair deficiency (dMMR) are validated tissue-agnostic biomarkers for PD-1 inhibitor response; pembrolizumab gained FDA tissue-agnostic approval in 2017 for MSI-H solid tumors, demonstrating that biomarker-driven targeting can succeed across cancer types.
events
vev_2f21af826c4ba233finding.assertedManual finding added to frontier state
agent:immuno-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_ee0d352cc378f53cfinding.addManual finding added to frontier state
applied · agent:immuno-research-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation rows are attached.