evidence boundary
unknowntheoretical
An evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
frontiers / frontier
Evidence atom
back to sourcesevidence boundary
unknownAn evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
finding binding
boundPediatric patients exhibit CYP3A4 hepatic metabolic rates reaching 30-40% of adult levels by 1 month postnatal, attaining adult levels only between 3-12 months; adult TMZ/alkylating-agent pharmacokinetics and dosing schedules are age-invalid.
inspect finding →
source binding
source-boundvs_104bf735f93e5b79
inspect source →
review context
unverified1 reviewable changes and 0 evaluation records target this atom or its bound objects.
Evidence statement
Pediatric patients exhibit CYP3A4 hepatic metabolic rates reaching 30-40% of adult levels by 1 month postnatal, attaining adult levels only between 3-12 months; adult TMZ/alkylating-agent pharmacokinetics and dosing schedules are age-invalid.
extraction method
manual_curation
support relation
unknown
condition refs
vcnd_61ef398544319e0a
Caveats
events
vev_091ed7d124a4975afinding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_53f6c7d335dfc6d4finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.