record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to staterecord state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding typeNo entity list is declared.
evidence
source-boundtheoretical · manual state transition
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
theoretical
conditions
Provenance
source title
Age-dependent CYP3A4 ontogeny physiologically based pharmacokinetic modeling
authors
reviewer:will-blair
Pediatric patients exhibit CYP3A4 hepatic metabolic rates reaching 30-40% of adult levels by 1 month postnatal, attaining adult levels only between 3-12 months; adult TMZ/alkylating-agent pharmacokinetics and dosing schedules are age-invalid.
vs_104bf735f93e5b79 · manual_curation
outgoing
vf_fdf73c97da49b959CYP3A4 age-dependent clearance invalidates adult-scaled temozolomide and irinotecan dosing in pediatric trials
events
vev_091ed7d124a4975afinding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_53f6c7d335dfc6d4finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation record targets this finding id.