evidence boundary
unknowntheoretical
An evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
frontiers / frontier
Evidence atom
back to sourcesevidence boundary
unknownAn evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
finding binding
boundONC201 activates the mitochondrial protease ClpP as a primary mechanism, inducing selective degradation of mitochondrial proteins, integrated stress response activation, and TRAIL-mediated apoptosis; ClpP expression is identified as a biomarker of response.
inspect finding →
source binding
source-boundvs_81559aa2458c0d83
inspect source →
review context
unverified1 reviewable changes and 0 evaluation records target this atom or its bound objects.
Evidence statement
ONC201 activates the mitochondrial protease ClpP as a primary mechanism, inducing selective degradation of mitochondrial proteins, integrated stress response activation, and TRAIL-mediated apoptosis; ClpP expression is identified as a biomarker of response.
extraction method
manual_curation
support relation
unknown
condition refs
vcnd_70575f7c6a5273b7
Caveats
events
vev_c8b3f32ff40a4c35finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_e15d2fcb42ec9007finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.