record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to staterecord state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding typeNo entity list is declared.
evidence
source-boundtheoretical · manual state transition
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
theoretical
conditions
Provenance
source title
Neuro-oncology mechanistic review and ClpP activation studies, 2023-2024
authors
reviewer:will-blair
ONC201 activates the mitochondrial protease ClpP as a primary mechanism, inducing selective degradation of mitochondrial proteins, integrated stress response activation, and TRAIL-mediated apoptosis; ClpP expression is identified as a biomarker of response.
vs_81559aa2458c0d83 · manual_curation
outgoing
vf_35f210ebd4b1b2c4ONC201 ClpP-stress mechanism works independently of PRC2 restoration; H3K27M chromatin effects not directly reversed
incoming
extends · vf_0fd7eaae574d9d92
supports · vf_26c616dc8e45573d
events
vev_c8b3f32ff40a4c35finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_e15d2fcb42ec9007finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation record targets this finding id.