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Pediatric high-grade glioma: distinct biology, distinct trials

CC-BY-4.0vfr_10815170943966df

id: vfr_10815170943966df
license: CC-BY-4.0
findings: 115
accepted core: 0
contested: 0

115

findings

76

links

113

sources

115

evidence

0

contested

0.82

avg conf

recordoverview state sources proofenginereviewbodygraph

Finding bundle

PDGFRA-positive oligodendrocyte precursor cell (OPC)-like subpopulations emerge as potential tumorigenic origins in H3G34-mutant hemispheric gliomas; these OPC-like cells at different differentiation states drive lineage transitions and maintain stemness properties essential for tumor maintenance.

2inferred

id: vf_0aa0b78694770236
frontier: Pediatric high-grade glioma: distinct biology, distinct trials
version: 1
confidence: 0.70

record state

frontier-owned

Review status

This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.

unreviewed

finding statement

finding type

mechanism

No entity list is declared.

evidence

source-bound

1 atoms

theoretical · manual state transition

proof impact

packet context

1 events

1 reviewable changes and 0 evaluation records are attached to this finding id.

Evidence and conditions

method

manual state transition

evidence type

theoretical

conditions

species_unverified
species_verified
text: scRNA-seq with CytoTRACE2, SCENT, pseudotime trajectory analysis; NGS and multiplex immunofluorescence validation

Provenance

source title

Tian et al. 2025 (10.1002/pdi3.70027); Single-Cell Profiling of Pediatric High-Grade Gliomas

authors

reviewer:will-blair

Source records

1

source record

Tian et al. 2025 (10.1002/pdi3.70027); Single-Cell Profiling of Pediatric High-Grade Gliomas

vs_9b05eaf26e3faeca

title:Tian et al. 2025 (10.1002/pdi3.70027); Single-Cell Profiling of Pediatric High-Grade Gliomas

2025manual_curation

inspect source →

Evidence atoms

1

vea_64383366e87613fetheoretical · unknown
PDGFRA-positive oligodendrocyte precursor cell (OPC)-like subpopulations emerge as potential tumorigenic origins in H3G34-mutant hemispheric gliomas; these OPC-like cells at different differentiation states drive lineage transitions and maintain stemness properties essential for tumor maintenance.
vs_9b05eaf26e3faeca · manual_curation

Typed links

3

outgoing

supportsvf_763a7009f1584ec6
OPC-like PDGFRA+ cells respond to CDK4/6 inhibition via ALT pathway

incoming

DMRTA2 transcription factor, highly expressed in radial glial progenitors during fetal brain development, is specifically upregulated in H3G34-mutant hemispheric gliomas and drives maintenance of radial-glia-like (RG) cell states; DMRTA2 loss impairs tumorigenicity and drives neuronal differentiation.
supports · vf_c3f5fea24271f673
H3G34-mutant hemispheric gliomas exhibit constitutively elevated H3K36me3 (trimethylation at H3 lysine 36), which disrupts normal chromatin architecture and represses genes normally silenced by H3K27me3, creating an epigenetic state intermediate between wildtype and H3K27M-mutant tumors.
depends · vf_28682e1efe7e242b

Review, event, and evaluation records

2

events

vev_ae1888c0ba947b4bfinding.asserted
Manual finding added to frontier state
reviewer:will-blair · 2026-05-29

reviewable changes

vpr_f7179814a2dbdad2finding.add
Manual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29

evaluations

No evaluation record targets this finding id.