record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to stateno incoming links yet
record state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding typeNo entity list is declared.
evidence
source-boundtheoretical · manual state transition
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
theoretical
conditions
Provenance
source title
Oncogenic Mechanisms of Histone H3 Mutations 2016 (10.1101/cshperspect.a026443); H3K36 trimethylation-mediated biological functions in cancer 2021 (10.1186/s13148-021-01187-2)
authors
reviewer:will-blair
H3G34-mutant hemispheric gliomas exhibit constitutively elevated H3K36me3 (trimethylation at H3 lysine 36), which disrupts normal chromatin architecture and represses genes normally silenced by H3K27me3, creating an epigenetic state intermediate between wildtype and H3K27M-mutant tumors.
vs_ce264e4fee4b4f7c · manual_curation
events
vev_e4a91253868b8ab3finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_0307c4ea948a95f7finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation record targets this finding id.