record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to stateno incoming links yet
record state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding typeNo entity list is declared.
evidence
source-boundtheoretical · manual state transition
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
theoretical
conditions
Provenance
source title
H3K27M mutant glioma: Disease definition and biological underpinnings (Neuro-Oncology, S92/7306459)
authors
reviewer:will-blair
H3K27M-mutant DMGs show a high-frequency, mutually exclusive association with ACVR1 mutations (R206H, R258G, G328E, G356E in kinase domain) that confer constitutive TGF-β signaling activation and enhanced proliferation in vitro
vs_82f5e05c9e1359d1 · manual_curation
outgoing
vf_de80700e4fa9447dACVR1 mutations co-occurring with H3K27M may activate PI3K/TGF-β pathways that synergize with H3K27M-driven stemness via CREB5/ID1
incoming
No incoming links.
events
vev_81148588da0a755cfinding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_586457e93582a3f0finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation record targets this finding id.