record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to staterecord state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding typeNo entity list is declared.
evidence
source-boundtheoretical · manual state transition
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
theoretical
conditions
Provenance
source title
An oncohistone-driven H3.3K27M/CREB5/ID1 axis maintains stemness (Nature Communications, s41467-025-58795-2)
authors
reviewer:will-blair
H3.3K27M drives context-dependent activation of the CREB5/ID1 axis via super-enhancer remodeling, maintaining stem-like transcriptional states; CREB5 inhibition or KDM6B targeting restores H3K27me3 and suppresses stemness in H3K27M-mutant cells
vs_3a7dc13a33032814 · manual_curation
outgoing
vf_0f3b43505f3ac327CREB5/ID1 axis maintenance of stemness is directly opposed by neuronal differentiation-inducing therapies
events
vev_1dbbac756b7a7eb4finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_60a4a57ba1d6b2eefinding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation record targets this finding id.