record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to stateno incoming links yet
record state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding type[object Object] · [object Object] · [object Object]
evidence
source-boundobservational · manual state transition
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
observational
conditions
Provenance
source title
Buczkowicz et al. Nat Genet 2014; Wu et al. Nat Genet 2014
authors
agent:phgg-research-bot-2026-05-09
DIPG/DMG biopsy biopsies (when performed) reveal frequent simultaneous H3K27M, ACVR1 (R206H), TP53, and PDGFRA mutations; the multi-driver landscape complicates single-target therapy and motivates combinations targeting the histone axis + downstream signaling.
vs_3911af7c1df96a9e · manual_curation
outgoing
No outgoing links.
incoming
No incoming links.
events
vev_2ac3aebc7a0718d3finding.assertedManual finding added to frontier state
agent:phgg-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_3718c02df0d64c70finding.addManual finding added to frontier state
applied · agent:phgg-research-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation record targets this finding id.