source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:Buczkowicz et al. Nat Genet 2014; Wu et al. Nat Genet 2014
imported
2026-05-09T22:22:51.070415+00:00
extraction mode
manual_curation
authors
agent:phgg-research-bot-2026-05-09
Caveats
No source-specific caveats are recorded.
DIPG/DMG biopsy biopsies (when performed) reveal frequent simultaneous H3K27M, ACVR1 (R206H), TP53, and PDGFRA mutations; the multi-driver landscape complicates single-target therapy and motivates combinations targeting the histone axis + downstream signaling.
events
vev_2ac3aebc7a0718d3finding.assertedManual finding added to frontier state
agent:phgg-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_3718c02df0d64c70finding.addManual finding added to frontier state
applied · agent:phgg-research-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation rows are attached.