record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to staterecord state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding typeNo entity list is declared.
evidence
source-boundtheoretical · manual state transition
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
theoretical
conditions
Provenance
source title
Nagaraja et al. 2017; Madhusoodanan et al. 2020 Cell Death & Disease
authors
reviewer:will-blair
H3K27M-induced global H3K27 hypomethylation is paradoxically accompanied by regional H3K27 hyperacetylation, driving super-enhancer activation and oncogenic transcription programs dependent on BRD4 and CBP.
vs_8871c659ca3e890d · manual_curation
outgoing
vf_bf703b393597cf63H3K27 epigenetic dysregulation (hypomet/hyperacet) drives super-enhancer programs targetable by combined epigenetic inhibition
events
vev_6da5014c9b617bd6finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_650cc753905c65cefinding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation record targets this finding id.