source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
external sourcelocator
title:Nagaraja et al. 2017; Madhusoodanan et al. 2020 Cell Death & Disease
imported
2026-05-29T02:50:58.535798+00:00
extraction mode
manual_curation
authors
reviewer:will-blair
Caveats
No source-specific caveats are recorded.
H3K27M-induced global H3K27 hypomethylation is paradoxically accompanied by regional H3K27 hyperacetylation, driving super-enhancer activation and oncogenic transcription programs dependent on BRD4 and CBP.
events
vev_6da5014c9b617bd6finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_650cc753905c65cefinding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.