record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to staterecord state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding typeNo entity list is declared.
evidence
source-boundtheoretical · manual state transition
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
theoretical
conditions
Provenance
source title
Therapeutically targeting the unique disease landscape of pediatric high-grade gliomas 2024 (10.3389/fonc.2024.1347694); A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon 2025 (10.1038/s41698-025-01070-w)
authors
reviewer:will-blair
H3G34-mutant hemispheric gliomas show poor response to conventional radiotherapy and chemotherapy (temozolomide + radiation standard regimens); emerging therapeutic strategies target metabolic vulnerabilities (PI3K/Akt pathway inhibition), ALT-associated DNA repair (PARP + CDK4/6 combinations), and immune microenvironment (CAR-T cells, oncolytic viruses).
vs_abac320e4b30b6c6 · manual_curation
outgoing
No outgoing links.
incoming
supports · vf_c807d05cc49c5ea8
supports · vf_038fff4583d6a364
events
vev_86a4d823c3f933e0finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_6f9471fc10707614finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation record targets this finding id.