source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:Therapeutically targeting the unique disease landscape of pediatric high-grade gliomas 2024 (10.3389/fonc.2024.1347694); A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon 2025 (10.1038/s41698-025-01070-w)
imported
2026-05-29T02:50:58.164760+00:00
extraction mode
manual_curation
authors
reviewer:will-blair
Caveats
No source-specific caveats are recorded.
H3G34-mutant hemispheric gliomas show poor response to conventional radiotherapy and chemotherapy (temozolomide + radiation standard regimens); emerging therapeutic strategies target metabolic vulnerabilities (PI3K/Akt pathway inhibition), ALT-associated DNA repair (PARP + CDK4/6 combinations), and immune microenvironment (CAR-T cells, oncolytic viruses).
events
vev_86a4d823c3f933e0finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_6f9471fc10707614finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.