source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
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frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
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Locator and citation
external sourcelocator
title:DMG patient-derived culture m6A profiling and FTO inhibitor studies, 2026
imported
2026-05-29T02:50:57.757121+00:00
extraction mode
manual_curation
authors
reviewer:will-blair
Caveats
No source-specific caveats are recorded.
H3K27M-mutant DMG exhibits elevated m6A (N6-methyladenosine) enrichment on cell-motility transcripts; FTO inhibition induces S-phase arrest and downregulates cell cycle regulators, revealing epi-transcriptomic vulnerability orthogonal to H3K27M's chromatin effects.
events
vev_dcb758885f6ae994finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_8af4cf97695818bdfinding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.