source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:ONC201 phase I dose escalation/expansion pediatric DMG trial, Neuro-Oncology
imported
2026-05-29T02:50:59.417593+00:00
extraction mode
manual_curation
authors
reviewer:will-blair
Caveats
No source-specific caveats are recorded.
ONC201 phase I pediatric DMG/DIPG trial established pediatric-weight-scaled dosing (adult RP2D 625 mg scaled to body weight) with recommended phase II dose determination—adult oncology regimens require de novo pediatric pharmacokinetic/pharmacodynamic validation.
events
vev_07a700809e50d72cfinding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_c9c2f49203860ed5finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.