Proposed change
reason
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
frontiers / frontier
Reviewable change
back to reviewClaudin-5 and occludin expression is reduced in cerebral microvasculature of early Alzheimer's disease post-mortem brain, paralleling the tight-junction breakdown observed in glioblastoma peritumoral vessels and consistent with a shared mechanism of BBB compromise across these otherwise unrelated diseases.
This is a proposal, not yet accepted frontier state. It names what it would change and who proposed it. Only an accepted review event, signed under reviewer authority, writes it into the frontier. Until then it carries no authority over the record.
Proposed change
reason
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
Provenance
proposed by
reviewer:will-blair
actor type
human
created at
2026-05-10
target type
finding
Affected finding
inspect finding →Claudin-5 and occludin expression is reduced in cerebral microvasculature of early Alzheimer's disease post-mortem brain, paralleling the tight-junction breakdown observed in glioblastoma peritumoral vessels and consistent with a shared mechanism of BBB compromise across these otherwise unrelated diseases.
vf_155dd090fb7c6ff7The diff is computed against current frontier state, the same diff a reviewer reads before deciding.
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Anti-amyloid translation in Alzheimer's disease receives a reviewable source, finding, caveat, replication, evaluation, or proof-affecting edit.
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